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. 2021 Apr 9:8:23742895211006832.
doi: 10.1177/23742895211006832. eCollection 2021 Jan-Dec.

Educational Case: Kidney Transplant Rejection

Kevin Kuan  1 , Daniel Schwartz  1
Affiliations

Educational Case: Kidney Transplant Rejection

Kevin Kuan et al. Acad Pathol. .

Abstract

The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and a full list of learning objectives for all three competencies, see http://journals.sagepub.com/doi/10.1177/2374289517715040.1.

Keywords: disease mechanisms; immune dysfunction; immunologic mechanisms; organ rejection; pathology competencies; transplantation.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Renal allograft ultrasonogram. A, The kidney is normal in appearance with no evidence of thrombosis, arterial thickening, hydronephrosis, or calculus formation. Note that there is a hypo-echoic loculated structure near the upper pole, implying fluid accumulation (arrowhead). B, Ultrasonographic enhancement by spectral imaging shows normal renal perfusion. The absence of spectral enhancement indicates the lack of fluid movement within the accumulation, which is suggestive of seroma.
Figure 2.
Figure 2.
Allograft kidney biopsy. A, Glomeruli are normal (periodic acid-Schiff stain, ×200). B, There is interstitial inflammation (hematoxylin and eosin stain, ×100). C, Tubulitis is present (arrowhead) (hematoxylin and eosin stain, ×400). D, Intimal arteritis is also present (arterial intima lymphocytic infiltration, arrowheads) (hematoxylin and eosin stain, ×200). E, There is focal peritubular capillary C4d staining (immunohistochemical stain, ×200).
See this image and copyright information in PMC

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