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. 2021 Aug 18;106(9):e3693-e3703.
doi: 10.1210/clinem/dgab270.

Timing of Pubertal Onset in Girls and Boys With Constitutional Delay

Elfa Jonsdottir-Lewis  1 , Amalia Feld  1 , Ryan Ciarlo  1 , Erica Denhoff  2 , Henry A Feldman  2 , Yee-Ming Chan  1   3
Affiliations

Timing of Pubertal Onset in Girls and Boys With Constitutional Delay

Elfa Jonsdottir-Lewis et al. J Clin Endocrinol Metab. .

Abstract

Context: The decision whether to treat a child with delayed puberty with sex steroids is primarily based on patient, family, and provider preference. Knowing when children with constitutional delay eventually enter puberty would inform this decision.

Objective, design, setting, participants, and outcome measures: To estimate and compare rates of pubertal entry, we conducted a retrospective cohort study by reviewing medical records of children evaluated for delayed puberty at a large academic medical center between 2000 and 2015, extracting data on pubertal status for all clinical visits, then conducting time-to-event analyses.

Results: Of 392 girls and 683 boys with delayed puberty, constitutional delay was the most common cause, found in 32% of girls and 70% of boys. In a subcohort of 97 girls and 243 boys who were prepubertal at one or more visits, we observed a broad age range for pubertal entry, up to >16 years for girls and >17 years for boys. The probability of entering puberty within the next year for 12- to 15.5-year-old girls and 13.5- to 16.5-year-old boys with delayed puberty ranged between 38% and 74%. No differences in the rates of pubertal entry were seen between girls and boys after data harmonization.

Conclusion: The broad range of ages at pubertal entry for children with constitutional delay challenges the concept that constitutional delay is merely an extreme of normal variation. Discussions with patients and families about management should consider the possibility that some children may need to wait years after presentation until puberty starts.

Keywords: constitutional delay; delayed puberty; hypogonadotropic hypogonadism.

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Figures

Figure 1.
Figure 1.
Patient records analyzed in this study. Detailed categories are provided in Supplemental Tables 1 and 2 (20).
Figure 2.
Figure 2.
Causes of delayed puberty in girls and boys. Figure modeled after ref. (21).
Figure 3.
Figure 3.
Probability of pubertal entry with age in (A) girls and (B) boys with unexplained delayed puberty because of constitutional delay or idiopathic hypogonadotropic hypogonadism; probability of entering puberty within the next 6 to 12 months by age for (C) girls and (D) boys of a given age; and probability of not entering puberty by age 18 years if still prepubertal at a given age for (E) girls and (F) boys.
Figure 4.
Figure 4.
Comparison between girls and boys of the probability of pubertal entry with age (expressed relative to age cutoffs used to define delayed puberty in this study [ie, 12 years for girls and 13.5 years for boys]).
See this image and copyright information in PMC

References

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