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Multicenter Study
. 2021:1335:37-44.
doi: 10.1007/5584_2021_635.

Outcome of Repeat Pulmonary Metastasectomy

Marcus Krüger  1 , Katharina Franzke  2 , Taufiek Konrad Rajab  3 , Fabian Nadler  4 , Moritz Möbius-Winkler  5 , Norman Zinne  6 , Daniel Schulz  4 , Miriam Möller  5 , Wolfgang Schütte  5 , Michael Ermitsch  4 , Bassam Redwan  7 , Olaf Schega  4 , Christian Biancosino  8
Affiliations
Multicenter Study

Outcome of Repeat Pulmonary Metastasectomy

Marcus Krüger et al. Adv Exp Med Biol. 2021.

Erratum in

  • Correction to: Outcome of Repeat Pulmonary Metastasectomy.
    Krüger M, Franzke K, Rajab TK, Nadler F, Möbius-Winkler M, Zinne N, Schulz D, Möller M, Schütte W, Ermitsch M, Redwan B, Schega O, Biancosino C. Krüger M, et al. Adv Exp Med Biol. 2021;1335:C1. doi: 10.1007/5584_2021_650. Adv Exp Med Biol. 2021. PMID: 34106447 No abstract available.

Abstract

Pulmonary metastasectomy is a well-established contribution to the cure of oligometastatic cancers, but its exact effectiveness is poorly understood. Here we report the outcomes of repeat pulmonary metastasectomy from a multicenter trial. This retrospective study included patients who underwent re-do metastasectomies between January 2010 and December 2014. The exclusion criterion was metastasectomy without curative intent. We reviewed medical files of 621 consecutive patients who underwent initial pulmonary metastasectomy. Of those, 64 patients underwent repeat metastasectomies, and these patients were included in the analysis. All the 64 patients underwent a second metastasectomy, later 35 of them underwent a third metastasectomy, 12 underwent a fourth metastasectomy, and 6 underwent a fifth metastasectomy. The total number of re-do metastasectomies was 181. The median overall survival among the patients undergoing re-do metastasectomy was 66.0 ± 3.8 months. Three and 5-year survival rates were 82.3% and 63.3%, respectively. The 5-year survival rates were 63.3% after the first, 50.9% after the second, 74.4% after the third, 83.3% after the fourth, and 60.0% after the fifth metastasectomy. We conclude that at the current stage of knowledge, there is an indication for repeat re-do metastasectomy with curative intent.

Keywords: Cancer; Lung metastases; Metastasectomy; Pulmonary metastasectomy; Survival.

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