Characteristics of SARS-CoV-2 variants of concern B.1.1.7, B.1.351 or P.1: data from seven EU/EEA countries, weeks 38/2020 to 10/2021

doi:10.2807/1560-7917.ES.2021.26.16.2100348

. 2021 Apr;26(16):2100348.

doi: 10.2807/1560-7917.ES.2021.26.16.2100348.

Characteristics of SARS-CoV-2 variants of concern B.1.1.7, B.1.351 or P.1: data from seven EU/EEA countries, weeks 38/2020 to 10/2021

Tjede Funk¹, Anastasia Pharris¹, Gianfranco Spiteri¹, Nick Bundle¹, Angeliki Melidou¹, Michael Carr^{2

3}, Gabriel Gonzalez^{2

3}, Alejandro Garcia-Leon⁴, Fiona Crispie⁵, Lois O'Connor⁶, Niamh Murphy⁶, Joël Mossong⁷, Anne Vergison⁷, Anke K Wienecke-Baldacchino⁸, Tamir Abdelrahman⁸, Flavia Riccardo⁹, Paola Stefanelli⁹, Angela Di Martino⁹, Antonino Bella⁹, Alessandra Lo Presti⁹, Pedro Casaca¹⁰, Joana Moreno¹⁰, Vítor Borges¹¹, Joana Isidro¹¹, Rita Ferreira¹¹, João Paulo Gomes¹¹, Liidia Dotsenko¹², Heleene Suija¹², Jevgenia Epstein¹², Olga Sadikova¹², Hanna Sepp¹², Niina Ikonen¹³, Carita Savolainen-Kopra¹³, Soile Blomqvist¹³, Teemu Möttönen¹³, Otto Helve¹³, Joana Gomes-Dias¹, Cornelia Adlhoch¹; COVID study groups¹⁴

Affiliations

¹ European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden.
² National Virus Reference Laboratory (NVRL), University College Dublin, Dublin, Ireland.
³ International Collaboration Unit, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan.
⁴ Centre for Experimental Pathogen Host Research, University College Dublin, Dublin, Ireland on behalf of the All Ireland Infectious Diseases (AIID) Cohort.
⁵ Teagasc Food Research Centre, Moorepark, Fermoy, Ireland on behalf of the Irish Coronavirus Sequencing Consortium (ICSC).
⁶ Health Service Executive - Health Protection Surveillance Centre (HPSC), Dublin, Ireland.
⁷ Health Directorate, Findel, Luxembourg.
⁸ National Health Laboratory, Dudelange, Luxembourg.
⁹ Istituto Superiore di Sanità, Rome, Italy.
¹⁰ Directorate of Analysis and Information, Directorate-General of Health, Lisbon, Portugal.
¹¹ Bioinformatics Unit, Infectious Diseases Department, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal.
¹² Health Board, Tallinn, Estonia.
¹³ Finnish Institute for Health and Welfare (THL), Department of Health Security, Helsinki, Finland.
¹⁴ The COVID study groups are listed at the end of this article under Acknowledgements.

PMID: 33890566
PMCID: PMC8063589
DOI: 10.2807/1560-7917.ES.2021.26.16.2100348

Characteristics of SARS-CoV-2 variants of concern B.1.1.7, B.1.351 or P.1: data from seven EU/EEA countries, weeks 38/2020 to 10/2021

Tjede Funk et al. Euro Surveill. 2021 Apr.

. 2021 Apr;26(16):2100348.

doi: 10.2807/1560-7917.ES.2021.26.16.2100348.

Authors

Affiliations

¹ European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden.
² National Virus Reference Laboratory (NVRL), University College Dublin, Dublin, Ireland.
³ International Collaboration Unit, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan.
⁴ Centre for Experimental Pathogen Host Research, University College Dublin, Dublin, Ireland on behalf of the All Ireland Infectious Diseases (AIID) Cohort.
⁵ Teagasc Food Research Centre, Moorepark, Fermoy, Ireland on behalf of the Irish Coronavirus Sequencing Consortium (ICSC).
⁶ Health Service Executive - Health Protection Surveillance Centre (HPSC), Dublin, Ireland.
⁷ Health Directorate, Findel, Luxembourg.
⁸ National Health Laboratory, Dudelange, Luxembourg.
⁹ Istituto Superiore di Sanità, Rome, Italy.
¹⁰ Directorate of Analysis and Information, Directorate-General of Health, Lisbon, Portugal.
¹¹ Bioinformatics Unit, Infectious Diseases Department, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal.
¹² Health Board, Tallinn, Estonia.
¹³ Finnish Institute for Health and Welfare (THL), Department of Health Security, Helsinki, Finland.
¹⁴ The COVID study groups are listed at the end of this article under Acknowledgements.

PMID: 33890566
PMCID: PMC8063589
DOI: 10.2807/1560-7917.ES.2021.26.16.2100348

Abstract

We compared 19,207 cases of SARS-CoV-2 variant B.1.1.7/S gene target failure (SGTF), 436 B.1.351 and 352 P.1 to non-variant cases reported by seven European countries. COVID-19 cases with these variants had significantly higher adjusted odds ratios for hospitalisation (B.1.1.7/SGTF: 1.7, 95% confidence interval (CI): 1.0-2.9; B.1.351: 3.6, 95% CI: 2.1-6.2; P.1: 2.6, 95% CI: 1.4-4.8) and B.1.1.7/SGTF and P.1 cases also for intensive care admission (B.1.1.7/SGTF: 2.3, 95% CI: 1.4-3.5; P.1: 2.2, 95% CI: 1.7-2.8).

Keywords: COVID-19; Europe; SARS-CoV-2; surveillance; variants of concern.

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Conflict of interest statement

Conflict of interest: None declared.

Figures

**Figure**
Reported SARS-CoV-2 VOC cases, by reporting country and week of reporting, EU/EEA, weeks 38/2020–10/2021 (n = 23,343)

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[1] Public Health England (PHE). Investigation of novel SARS-CoV-2 variant - variant of concern 202012/01. London: PHE; 2020. Available from: https://assets.publishing.service.gov.uk/government/uploads/system/uploa...

[2] Public Health England (PHE). Investigation of novel SARS-CoV-2 variant - variant of concern 202012/01. London: PHE; 2020. Available from: https://assets.publishing.service.gov.uk/government/uploads/system/uploa...

[3] European Centre for Disease Prevention and Control (ECDC). Risk assessment: Risk related to spread of new SARS-CoV-2 variants of concern in the EU/EEA - first update. Stockholm: ECDC; 2021. Available from: https://www.ecdc.europa.eu/en/publications-data/covid-19-risk-assessment...

[4] European Centre for Disease Prevention and Control (ECDC). Risk assessment: Risk related to spread of new SARS-CoV-2 variants of concern in the EU/EEA - first update. Stockholm: ECDC; 2021. Available from: https://www.ecdc.europa.eu/en/publications-data/covid-19-risk-assessment...

[5] Japanese National Institute of Infectious Diseases (NIID). Brief report: new variant strain of SARS-CoV-2 identified in travelers from Brazil: Tokyo: NIID; 2021. Available from: https://www.niid.go.jp/niid/en/2019-ncov-e/10108-covid19-33-en.html

[6] Japanese National Institute of Infectious Diseases (NIID). Brief report: new variant strain of SARS-CoV-2 identified in travelers from Brazil: Tokyo: NIID; 2021. Available from: https://www.niid.go.jp/niid/en/2019-ncov-e/10108-covid19-33-en.html

[7] Faria NR, Claro IM, Candido D, Franco LAM, Andrade PS, Coletti TM, et al. Genomic characterisation of an emergent SARS-CoV-2 lineage in Manaus: preliminary findings. Virological.org. 2021. Available from: https://virological.org/t/genomic-characterisation-of-an-emergent-sars-c...

[8] Faria NR, Claro IM, Candido D, Franco LAM, Andrade PS, Coletti TM, et al. Genomic characterisation of an emergent SARS-CoV-2 lineage in Manaus: preliminary findings. Virological.org. 2021. Available from: https://virological.org/t/genomic-characterisation-of-an-emergent-sars-c...

[9] Tegally H, Wilkinson E, Giovanetti M, Iranzadeh A, Fonseca V, Giandhari J, et al. Emergence and rapid spread of a new severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) lineage with multiple spike mutations in South Africa. medRxiv. 2020:2020.12.21.20248640. 10.1101/2020.12.21.20248640 - DOI

[10] Tegally H, Wilkinson E, Giovanetti M, Iranzadeh A, Fonseca V, Giandhari J, et al. Emergence and rapid spread of a new severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) lineage with multiple spike mutations in South Africa. medRxiv. 2020:2020.12.21.20248640. 10.1101/2020.12.21.20248640 - DOI

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Characteristics of SARS-CoV-2 variants of concern B.1.1.7, B.1.351 or P.1: data from seven EU/EEA countries, weeks 38/2020 to 10/2021

Affiliations

Characteristics of SARS-CoV-2 variants of concern B.1.1.7, B.1.351 or P.1: data from seven EU/EEA countries, weeks 38/2020 to 10/2021

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