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Comment
. 2021 Jun 1;320(6):H2185-H2187.
doi: 10.1152/ajpheart.00194.2021. Epub 2021 Apr 23.

Find the stimulus, save the heart: a heroes' story

Baylee Westbury  1 , Dawson Bolus  1 , Kristine Y DeLeon-Pennell  1   2
Affiliations
Comment

Find the stimulus, save the heart: a heroes' story

Baylee Westbury et al. Am J Physiol Heart Circ Physiol. .
No abstract available

Keywords: fibroblasts; fibrosis; macrophage; wound healing.

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Conflict of interest statement

No conflicts of interest, financial or otherwise, are declared by the authors.

Figures

Figure 1.
Figure 1.
Overview of the NF-κB pathway in young and aging hearts after stress or damage. Both P1, regenerative hearts, and P8, nonregenerative hearts, express NF-κB immediately after myocardial infraction (MI). Neonate P1 hearts trigger the signal transducer and activator of transcription 3 (STAT3) pathway, resulting in the expression of suppressor of cytokine signaling 3 (SOCS3). SOCS3 inhibits the activity of NF-κB, stopping the inflammatory pathway prematurely and resulting in minimal scar formation. Aging hearts experience a prolonged NF-κB response leading to more fibrosis after damage. Created with BioRender.com and published with permission.
See this image and copyright information in PMC

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