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Comment
. 2021 May 10;39(5):598-600.
doi: 10.1016/j.ccell.2021.03.009. Epub 2021 Apr 22.

Bacteria break barrier to promote metastasis

Yoshitaka Murota  1 , Christian Jobin  2
Affiliations
Comment

Bacteria break barrier to promote metastasis

Yoshitaka Murota et al. Cancer Cell. .

Abstract

The intestinal microbiota promote colorectal cancer, but their role in metastasis is poorly defined. In this issue of Cancer Cell, Bertocchi et al. report that intratumoral bacteria disrupt the gut vascular barrier, causing bacterial dissemination to the liver and the formation of a premetastatic niche, favoring recruitment of metastatic cells.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Figures

Figure 1.
Figure 1.. Schematic representation of CRC liver metastasis facilitated by VirF+ E. coli
Intratumor Virf+ E. coli (step 1) breaks down the GVB associated with increased expression of PV-1 (step 2), allowing the translocation of gut microbes to the liver (step 3). Disseminated microbes colonize the liver (step 4) and establish a PMN microenvironment that features increased expression of chemotactic factors and ECM deposition (step 5). Primary colorectal cancer cells metastasize to the liver, where implantation is facilitated by PMN (step 6). Created by Biorender.com
See this image and copyright information in PMC

Comment on

  • Gut vascular barrier impairment leads to intestinal bacteria dissemination and colorectal cancer metastasis to liver.
    Bertocchi A, Carloni S, Ravenda PS, Bertalot G, Spadoni I, Lo Cascio A, Gandini S, Lizier M, Braga D, Asnicar F, Segata N, Klaver C, Brescia P, Rossi E, Anselmo A, Guglietta S, Maroli A, Spaggiari P, Tarazona N, Cervantes A, Marsoni S, Lazzari L, Jodice MG, Luise C, Erreni M, Pece S, Di Fiore PP, Viale G, Spinelli A, Pozzi C, Penna G, Rescigno M. Bertocchi A, et al. Cancer Cell. 2021 May 10;39(5):708-724.e11. doi: 10.1016/j.ccell.2021.03.004. Epub 2021 Apr 1. Cancer Cell. 2021. PMID: 33798472

References

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