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Comment
. 2021 Jun;7(6):482-483.
doi: 10.1016/j.trecan.2021.03.002. Epub 2021 Apr 21.

Synovial Sarcoma Oncogenesis Revealed by Single-Cell Profiling

Alvin Qiu  1 , Torsten O Nielsen  2
Affiliations
Comment

Synovial Sarcoma Oncogenesis Revealed by Single-Cell Profiling

Alvin Qiu et al. Trends Cancer. 2021 Jun.

Abstract

Synovial sarcoma is a soft tissue malignancy driven by the SS18-SSX fusion oncoprotein. In Nature Medicine, Jerby-Arnon et al. present a single-cell dataset for synovial sarcoma that reveals a novel 'core oncogenic program' driven by SS18-SSX, with implications for treatment strategies based on epigenetics, cell-cycle control, and immune augmentation.

Keywords: SS18–SSX; epigenetics; immune exclusion; single-cell; synovial sarcoma.

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  • Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma.
    Jerby-Arnon L, Neftel C, Shore ME, Weisman HR, Mathewson ND, McBride MJ, Haas B, Izar B, Volorio A, Boulay G, Cironi L, Richman AR, Broye LC, Gurski JM, Luo CC, Mylvaganam R, Nguyen L, Mei S, Melms JC, Georgescu C, Cohen O, Buendia-Buendia JE, Segerstolpe A, Sud M, Cuoco MS, Labes D, Gritsch S, Zollinger DR, Ortogero N, Beechem JM, Petur Nielsen G, Chebib I, Nguyen-Ngoc T, Montemurro M, Cote GM, Choy E, Letovanec I, Cherix S, Wagle N, Sorger PK, Haynes AB, Mullen JT, Stamenkovic I, Rivera MN, Kadoch C, Wucherpfennig KW, Rozenblatt-Rosen O, Suvà ML, Riggi N, Regev A. Jerby-Arnon L, et al. Nat Med. 2021 Feb;27(2):289-300. doi: 10.1038/s41591-020-01212-6. Epub 2021 Jan 25. Nat Med. 2021. PMID: 33495604 Free PMC article.

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