Integration of evidence across human and model organism studies: A meeting report

Rohan H C Palmer¹, Emma C Johnson², Hyejung Won³, Renato Polimanti⁴, Manav Kapoor⁵, Apurva Chitre⁶, Molly A Bogue⁷, Chelsie E Benca-Bachman¹, Clarissa C Parker⁸, Anurag Verma⁹, Timothy Reynolds⁷, Jason Ernst¹⁰, Michael Bray², Soo Bin Kwon¹⁰, Dongbing Lai¹¹, Bryan C Quach¹², Nathan C Gaddis¹², Laura Saba¹³, Hao Chen¹⁴, Michael Hawrylycz¹⁵, Shan Zhang¹⁶, Yuan Zhou¹⁷, Spencer Mahaffey¹⁸, Christian Fischer¹⁹, Sandra Sanchez-Roige⁶, Anita Bandrowski²⁰, Qing Lu¹⁷, Li Shen⁵, Vivek Philip⁷, Joel Gelernter⁴, Laura J Bierut², Dana B Hancock¹², Howard J Edenberg^{11

21}, Eric O Johnson¹², Eric J Nestler⁵, Peter B Barr²², Pjotr Prins¹⁹, Desmond J Smith²³, Schahram Akbarian²⁴, Thorgeir Thorgeirsson²⁵, Dave Walton⁷, Erich Baker²⁶, Daniel Jacobson^{27

28}, Abraham A Palmer^{6

29}, Michael Miles³⁰, Elissa J Chesler⁷, Jake Emerson⁷, Arpana Agrawal², Maryann Martone²⁰, Robert W Williams¹⁹

Affiliations

¹ Behavioral Genetics of Addiction Laboratory, Department of Psychology, Emory University, Atlanta, Georgia, USA.
² Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.
³ Department of Genetics and Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
⁴ Department of Psychiatry, Yale University School of Medicine, West Haven, Connecticut, USA.
⁵ Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
⁶ Department of Psychiatry, University of California, San Diego, La Jolla, California, USA.
⁷ The Jackson Laboratory, Bar Harbor, Maine, USA.
⁸ Department of Psychology and Program in Neuroscience, Middlebury College, Middlebury, Vermont, USA.
⁹ Biomedical and Translational Informatics Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
¹⁰ Department of Biological Chemistry, University of California Los Angeles, Los Angeles, California, USA.
¹¹ Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
¹² GenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, North Carolina, USA.
¹³ Department of Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.
¹⁴ Department of Pharmacology, Addiction Science, and Toxicology, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
¹⁵ Allen Institute, Seattle, Washington, USA.
¹⁶ Department of Statistics and Probability, Michigan State University, East Lansing, Michigan, USA.
¹⁷ Department of Department of Biostatistics, University of Florida, Gainesville, Florida, USA.
¹⁸ Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Denver, Aurora, Colorado, USA.
¹⁹ Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
²⁰ Department of Neuroscience, University of California, San Diego, La Jolla, California, USA.
²¹ Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
²² Department of Psychology, Virginia Commonwealth University, Richmond, Virginia, USA.
²³ Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.
²⁴ Friedman Brain Institute and Departments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
²⁵ deCODE Genetics/Amgen Inc., Reykjavik, Iceland.
²⁶ Department of Computer Science, Baylor University, Waco, Texas, USA.
²⁷ Computational and Predictive Biology, Biosciences, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA.
²⁸ Department of Psychology, University of Tennessee Knoxville, Knoxville, Tennessee, USA.
²⁹ Institute for Genomic Medicine, University of California San Diego, La Jolla, California, USA.
³⁰ Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia, USA.

PMID: 33893716
PMCID: PMC8365690
DOI: 10.1111/gbb.12738

Review

Integration of evidence across human and model organism studies: A meeting report

Rohan H C Palmer et al. Genes Brain Behav. 2021.

. 2021 Apr 23;20(6):e12738.

doi: 10.1111/gbb.12738. Online ahead of print.

Authors

Affiliations

¹ Behavioral Genetics of Addiction Laboratory, Department of Psychology, Emory University, Atlanta, Georgia, USA.
² Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.
³ Department of Genetics and Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
⁴ Department of Psychiatry, Yale University School of Medicine, West Haven, Connecticut, USA.
⁵ Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
⁶ Department of Psychiatry, University of California, San Diego, La Jolla, California, USA.
⁷ The Jackson Laboratory, Bar Harbor, Maine, USA.
⁸ Department of Psychology and Program in Neuroscience, Middlebury College, Middlebury, Vermont, USA.
⁹ Biomedical and Translational Informatics Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
¹⁰ Department of Biological Chemistry, University of California Los Angeles, Los Angeles, California, USA.
¹¹ Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
¹² GenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, North Carolina, USA.
¹³ Department of Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.
¹⁴ Department of Pharmacology, Addiction Science, and Toxicology, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
¹⁵ Allen Institute, Seattle, Washington, USA.
¹⁶ Department of Statistics and Probability, Michigan State University, East Lansing, Michigan, USA.
¹⁷ Department of Department of Biostatistics, University of Florida, Gainesville, Florida, USA.
¹⁸ Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Denver, Aurora, Colorado, USA.
¹⁹ Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
²⁰ Department of Neuroscience, University of California, San Diego, La Jolla, California, USA.
²¹ Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
²² Department of Psychology, Virginia Commonwealth University, Richmond, Virginia, USA.
²³ Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.
²⁴ Friedman Brain Institute and Departments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
²⁵ deCODE Genetics/Amgen Inc., Reykjavik, Iceland.
²⁶ Department of Computer Science, Baylor University, Waco, Texas, USA.
²⁷ Computational and Predictive Biology, Biosciences, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA.
²⁸ Department of Psychology, University of Tennessee Knoxville, Knoxville, Tennessee, USA.
²⁹ Institute for Genomic Medicine, University of California San Diego, La Jolla, California, USA.
³⁰ Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia, USA.

PMID: 33893716
PMCID: PMC8365690
DOI: 10.1111/gbb.12738

Abstract

The National Institute on Drug Abuse and Joint Institute for Biological Sciences at the Oak Ridge National Laboratory hosted a meeting attended by a diverse group of scientists with expertise in substance use disorders (SUDs), computational biology, and FAIR (Findability, Accessibility, Interoperability, and Reusability) data sharing. The meeting's objective was to discuss and evaluate better strategies to integrate genetic, epigenetic, and 'omics data across human and model organisms to achieve deeper mechanistic insight into SUDs. Specific topics were to (a) evaluate the current state of substance use genetics and genomics research and fundamental gaps, (b) identify opportunities and challenges of integration and sharing across species and data types, (c) identify current tools and resources for integration of genetic, epigenetic, and phenotypic data, (d) discuss steps and impediment related to data integration, and (e) outline future steps to support more effective collaboration-particularly between animal model research communities and human genetics and clinical research teams. This review summarizes key facets of this catalytic discussion with a focus on new opportunities and gaps in resources and knowledge on SUDs.

Keywords: GWAS; cross-species; data integration; drug abuse; genomics; model organisms; multi-omic; substance use disorders; working group.

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Conflict of interest statement

The authors have no conflicts to declare.

References

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Integration of evidence across human and model organism studies: A meeting report

Affiliations

Integration of evidence across human and model organism studies: A meeting report

Authors

Affiliations

Abstract

Conflict of interest statement

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