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. 2021 Apr;170(6):744-747.
doi: 10.1007/s10517-021-05146-y. Epub 2021 Apr 24.

Reduced Expression of Extracellular Matrix Proteins in the Heart and Kidneys of Rats with Endotoxemia under the Effect of Actinonin

D A Chepurnova  1 , E V Samoilova  2 , А G Fesenko  1 , А А Korotaeva  1
Affiliations

Reduced Expression of Extracellular Matrix Proteins in the Heart and Kidneys of Rats with Endotoxemia under the Effect of Actinonin

D A Chepurnova et al. Bull Exp Biol Med. 2021 Apr.

Abstract

We studied modulation of the expression of extracellular matrix proteins under conditions of meprin inhibition in rats with LPS-induced endotoxemia. Endotoxemia increased the expression of type I, III, IV collagens and fibronectin in the renal tissue and type III and IV collagens in the heart. Meprin inhibitor actinonin reduced expression of both meprins and genes of extracellular matrix proteins, but the intensity of this effect in the heart and kidney was different. Inhibition of meprins in endotoxemia can prevent pathological remodeling of the extracellular matrix in the heart and kidney.

Keywords: actinonin; collagens; extracellular matrix; gene expression; meprins.

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