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. 2021 Apr 24;21(1):459.
doi: 10.1186/s12885-021-08217-5.

Global, regional, and national mortality trends of female breast cancer by risk factor, 1990-2017

Hui Liu #  1 , Wenjie Shi #  2 , Zhi Jin #  3 , Rui Zhuo  4 , Jie Dong  4 , Qiufeng Lao  1 , Shengle Li  1 , Weiyi Pang  5
Affiliations

Global, regional, and national mortality trends of female breast cancer by risk factor, 1990-2017

Hui Liu et al. BMC Cancer. .

Abstract

Background: Female breast cancer (FBC) is a malignancy involving multiple risk factors and has imposed heavy disease burden on women. We aim to analyze the secular trends of mortality rate of FBC according to its major risk factors.

Methods: Death data of FBC at the global, regional, and national levels were retrieved from the online database of Global Burden of Disease study 2017. Deaths of FBC attributable to alcohol use, high body-mass index (BMI), high fasting plasma glucose (FPG), low physical activity, and tobacco were collected. Estimated average percentage change (EAPC) was used to quantify the temporal trends of age-standardized mortality rate (ASMR) of FBC in 1990-2017.

Results: Worldwide, the number of deaths from FBC increased from 344.9 thousand in 1990 to 600.7 thousand in 2017. The ASMR of FBC decreased by 0.59% (95% CI, 0.52, 0.66%) per year during the study period. This decrease was largely driven by the reduction in alcohol use- and tobacco-related FBC, of which the ASMR was decreased by 1.73 and 1.77% per year, respectively. In contrast, the ASMR of FBC attributable to high BMI and high FPG was increased by 1.26% (95% CI, 1.22, 1.30%) and 0.26% (95% CI, 0.23, 0.30%) per year between 1990 and 2017, respectively.

Conclusions: The mortality rate of FBC experienced a reduction over the last three decades, which was partly owing to the effective control for alcohol and tobacco use. However, more potent and tailored prevention strategies for obesity and diabetes are urgently warranted.

Keywords: Alcohol; Diabetes; Female breast cancer; Mortality; Obesity; Smoking.

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Conflict of interest statement

None

Figures

Fig. 1
Fig. 1
The temporal trends of death number and mortality rate of female breast cancer (FBC) at the global level. a, the increasing trend of death number of FBC; b, the proportions of FBC related deaths attributable to different risk factors; c, the decreasing trend of age-standardized mortality rate of FBC; d, the temporal trends of FBC attributable to different risk factors)
Fig. 2
Fig. 2
The estimated average percentage change (EAPC) of mortality rate of female breast cancer (FBC) at the global and regional level by risk factor
Fig. 3
Fig. 3
The global distribution of age-standardized mortality rate of female breast cancer (FBC) by risk factor (a to f displays the mortality of FBC attributable to all causes, alcohol use, high BMI, high fasting plasma glucose, low physical activity, and tobacco, respectively)
Fig. 4
Fig. 4
The estimated average percentage change (EAPC) of mortality rate of female breast cancer (FBC) at the national level by risk factor (a to f displays the EAPC of FBC attributable to all causes, alcohol use, high BMI, high fasting plasma glucose, low physical activity, and tobacco, respectively)
Fig. 5
Fig. 5
The proportions of female breast cancer related deaths attributable to different risk factors at the global and regional level
See this image and copyright information in PMC

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