Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2021 Jul;46(7):519-521.
doi: 10.1016/j.tibs.2021.03.005. Epub 2021 Apr 22.

How NS1 Antibodies Prevent Severe Flavivirus Disease

Justin S G Ooi  1 , Shee-Mei Lok  2
Affiliations
Comment

How NS1 Antibodies Prevent Severe Flavivirus Disease

Justin S G Ooi et al. Trends Biochem Sci. 2021 Jul.

Abstract

The flavivirus genus consists of several major human pathogens including dengue (DENV) and Zika viruses. The flavivirus nonstructural protein 1 (NS1) plays an important role in disease progression, for example, in the development of severe dengue disease. Anti-NS1 antibodies have been shown to confer protection, and two new studies by Biering et al. and Modhiran et al. on the structure of NS1:antibody complexes reveal their mechanism of neutralization.

Keywords: antibody; flavivirus; nonstructural protein 1 (NS1); structural biology.

PubMed Disclaimer

Comment on

  • A broadly protective antibody that targets the flavivirus NS1 protein.
    Modhiran N, Song H, Liu L, Bletchly C, Brillault L, Amarilla AA, Xu X, Qi J, Chai Y, Cheung STM, Traves R, Setoh YX, Bibby S, Scott CAP, Freney ME, Newton ND, Khromykh AA, Chappell KJ, Muller DA, Stacey KJ, Landsberg MJ, Shi Y, Gao GF, Young PR, Watterson D. Modhiran N, et al. Science. 2021 Jan 8;371(6525):190-194. doi: 10.1126/science.abb9425. Science. 2021. PMID: 33414219
  • Structural basis for antibody inhibition of flavivirus NS1-triggered endothelial dysfunction.
    Biering SB, Akey DL, Wong MP, Brown WC, Lo NTN, Puerta-Guardo H, Tramontini Gomes de Sousa F, Wang C, Konwerski JR, Espinosa DA, Bockhaus NJ, Glasner DR, Li J, Blanc SF, Juan EY, Elledge SJ, Mina MJ, Beatty PR, Smith JL, Harris E. Biering SB, et al. Science. 2021 Jan 8;371(6525):194-200. doi: 10.1126/science.abc0476. Science. 2021. PMID: 33414220 Free PMC article.

Substances