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Review
. 2021 Oct;26(10):2303-2314.
doi: 10.1016/j.drudis.2021.04.013. Epub 2021 Apr 22.

Epigenetics and therapeutic targets in gastrointestinal malignancies

Ganji Purnachandra Nagaraju  1 , Prameswari Kasa  2 , Begum Dariya  3 , Nagalakshmi Surepalli  4 , Sujatha Peela  5 , Sarfraz Ahmad  6
Affiliations
Review

Epigenetics and therapeutic targets in gastrointestinal malignancies

Ganji Purnachandra Nagaraju et al. Drug Discov Today. 2021 Oct.

Abstract

Gastrointestinal (GI) malignancies account for substantial mortality and morbidity worldwide. They are generally promoted by dysregulated signal transduction and epigenetic pathways, which are controlled by specific enzymes. Recent studies demonstrated that histone deacetylases (HDACs) together with DNA methyltransferases (DNMTs) have crucial roles in the signal transduction/epigenetic pathways in GI regulation. In this review, we discuss various enzyme targets and their functional mechanisms responsible for the regulatory processes of GI malignancies. We also discuss the epigenetic therapeutic targets that are mainly facilitated by DNMT and HDAC inhibitors, which have functional consequences and clinical outcomes for GI malignancies.

Keywords: Clinical outcomes; DNA methyltransferases; Epigenetics; Gastrointestinal cancers; Histone deacetylases; Therapy.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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