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Review
. 2021 Jun:58:62-67.
doi: 10.1016/j.coph.2021.03.008. Epub 2021 Apr 22.

Current status of hepatitis delta

Margarita Papatheodoridi  1 , George V Papatheodoridis  2
Affiliations
Review

Current status of hepatitis delta

Margarita Papatheodoridi et al. Curr Opin Pharmacol. 2021 Jun.

Abstract

Hepatitis D virus (HDV) infection in patients chronically infected with hepatitis B virus (HBV) causes the most severe form of chronic viral hepatitis and continues to represent a major health problem. The latest data show that the global prevalence is much higher than previously considered. Therefore, screening with the detection of anti-HDV antibodies is mandatory for all chronic HBV patients. In spite of the severity of liver disease, the only recommended treatment today is pegylated interferon-alpha, which has limited efficacy. Novel host-targeting molecules are now under investigation. The current phase 2 clinical trials include pegylated interferon-lambda, bulevirtide, lonafarnib, and REP-2139. This review focuses on the current status of epidemiology, diagnosis, and treatment of HDV infection.

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Conflict of interest statement

Conflict of interest statement M Papatheodoridi has no conflict of interest; G Papatheodoridis has served as advisor/lecturer for, has received research grants from, and has participated in clinical trials sponsored by Gilead Sciences; he has participated as principal investigator in clinical trials sponsored by Eiger BioPharmaceuticals.