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Comment
. 2021 Apr 24;6(1):164.
doi: 10.1038/s41392-021-00601-8.

Adapt or perish: SARS-CoV-2 antibody escape variants defined by deletions in the Spike N-terminal Domain

Marta Ribes  1 , Carlos Chaccour #  2   3   4 , Gemma Moncunill #  1
Affiliations
Comment

Adapt or perish: SARS-CoV-2 antibody escape variants defined by deletions in the Spike N-terminal Domain

Marta Ribes et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
A pattern of recurrent deletions in the NTD of the Spike was observed by McCarthy et al. RDRs were identified in an immunocompromised patient, in late but not baseline samples of eight COVID-19 patients and in 1108 sequences originating in diverse geographic sites. Center: representation of SARS-CoV-2 spike by David S. Goodsell and the Research Collaboratory for Structural Bioinformatics Protein Data Bank. Top right: the location of the RDRs is represented and delimited by the numbered amino acid. Bottom right: indirect immunofluorescence showed that the RDR2 and RDR4 deletions in S expressed on the surface of Vero E6 cells abrogated the binding of the 4A8 monoclonal antibody. Non-plaque-purified viral population from the immunocompromised patient showed resistance to neutralization by 4A8, but was neutralized by polyclonal antisera from convalescent patients
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References

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