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Review
. 2021 Sep;476(9):3319-3328.
doi: 10.1007/s11010-021-04160-y. Epub 2021 Apr 25.

Non-coding RNA: insights into the mechanism of methamphetamine neurotoxicity

Ying-Jian Gu  1 , Lei Chen  1 , Lin Cheng  1 , Ming-Yuan Zhou  1 , Yun Wang  2
Affiliations
Review

Non-coding RNA: insights into the mechanism of methamphetamine neurotoxicity

Ying-Jian Gu et al. Mol Cell Biochem. 2021 Sep.

Abstract

Chronic exposure of the methamphetamine has been shown to lead to neurotoxicity in rodents and humans. The manifestations of methamphetamine neurotoxicity include methamphetamine use disorder, methamphetamine abuse, methamphetamine addiction and methamphetamine behavioral sensitization. Repeated use of methamphetamine can cause methamphetamine use disorder. The abuse and addiction of methamphetamine are growing epidemic worldwide. Repeated intermittent exposure to methamphetamine can cause behavioral sensitization. In addition, many studies have shown that changes in the expression of non-coding RNA in the ventral tegmental area and nucleus accumbens will affect the behavioral effects of methamphetamine. Non-coding RNA plays an important role in the behavioral effects of methamphetamine. Therefore, it is important to study the relationship between methamphetamine and non-coding RNA. The purpose of this review is to study the non-coding RNA associated with methamphetamine neurotoxicity to search for the possible therapeutic target of the methamphetamine neurotoxicity.

Keywords: Addiction; Drug abuse; Locomotor sensitization; Methamphetamine; Neurotoxicity; Non-coding RNA; Use disorder.

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