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. 2021 Mar;497(1):63-65.
doi: 10.1134/S1607672921020101. Epub 2021 Apr 24.

Angiogenic Effects of Anxiolytic Fabomotizole

S A Kryzhanovskii  1 , T A Antipova  2 , M B Vititnova  2 , S V Nikolaev  2 , A D Durnev  2
Affiliations

Angiogenic Effects of Anxiolytic Fabomotizole

S A Kryzhanovskii et al. Dokl Biochem Biophys. 2021 Mar.

Abstract

In vitro experiments performed on an isolated human endothelial HUVEC cell culture showed that the anxiolytic fabomotizole, which, in addition to the anxiolytic effect, has neuroprotective and cardioprotective activities largely associated with its agonistic action on sigma-1 receptors and shows a pronounced angiogenic activity. Fabomotizole angiogenic activity is realized in the range concentration from 10-5 to 10-8 M and is doze-dependent. In the literature, data on the presence of angiogenic activity in sigma receptor agonists have not been previously reported.

Keywords: angiogenesis; cytoprotection; fabomotizole; human endothelial cells HUVEC; sigma-1 receptors.

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