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Review
. 2021 Apr;48(4):3827-3840.
doi: 10.1007/s11033-021-06363-4. Epub 2021 Apr 25.

Toxic proteins application in cancer therapy

Zahra Setayesh-Mehr  1 , Mahdiye Poorsargol  2
Affiliations
Review

Toxic proteins application in cancer therapy

Zahra Setayesh-Mehr et al. Mol Biol Rep. 2021 Apr.

Abstract

Ribosome inactivating proteins (RIPs) as family of anti-cancer drugs recently received much attention due to their interesting anti-cancer mechanism. In spite of small drugs, RIPs use the large-size effect (LSE) to prevent the efflux process governed by drug resistance transporters (DRTs) which prevents inside of the cells against drug transfection. There are many clinical translation obstacles that severely restrict their applications especially their delivery approach to the tumor cells. As the main goal of this review, we will focus on trichosanthin (TCS) and gelonin (Gel) and other types, especially scorpion venom-derived RIPs to clarify that they are struggling with what types of bio-barriers and these challenges could be solved in cancer therapy science. Then, we will try to highlight recent state-of-the-arts in delivery of RIPs for cancer therapy.

Keywords: Cancer; Cytotoxicity; Drug delivery; Proteins; Scorpion venom; Tumor.

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References

    1. Shapira A, Benhar I (2010) Toxin-based therapeutic approaches. Toxins 2(11):2519–2583. https://doi.org/10.3390/toxins2112519 - DOI - PubMed - PMC
    1. Maraganore JM, Joseph M, Bailey MC (1987) Purification and characterization of trichosanthin. Homology to the ricin A chain and implications as to mechanism of abortifacient activity. J Biol Chem 262(24):11628–11633. https://doi.org/10.1016/S0021-9258(18)60855-5 - DOI - PubMed
    1. Shi WW, Wong KB, Shaw PC (2018) Structural and functional investigation and pharmacological mechanism of trichosanthin, a type 1 ribosome-inactivating protein. Toxins 10(8):335. https://doi.org/10.3390/toxins10080335 - DOI - PMC
    1. Zhang C, Gong Y, Ma H, An C, Chen ZL (2001) Reactive oxygen species involved in trichosanthin-induced apoptosis of human choriocarcinoma cells. Biochem J 355(3):653–661. https://doi.org/10.1042/bj3550653 - DOI - PubMed - PMC
    1. Li M, Li X, Li JC (2010) Possible mechanisms of trichosanthin-induced apoptosis of tumor cells. Anat Rec 293(6):986–992. https://doi.org/10.1002/ar.21142 - DOI

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