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Review
. 2021 Jul;51(7):1602-1614.
doi: 10.1002/eji.202048812. Epub 2021 May 13.

Neuroimmune interactions in peripheral tissues

Christoph S N Klose  1 , Henrique Veiga-Fernandes  2
Affiliations
Free article
Review

Neuroimmune interactions in peripheral tissues

Christoph S N Klose et al. Eur J Immunol. 2021 Jul.
Free article

Abstract

Neuroimmune interactions have been revealed to be at the centre stage of tissue defence, organ homeostasis, and organismal physiology. Neuronal and immune cell subsets have been shown to colocalize in discrete tissue environments, forming neuroimmune cell units that constitute the basis for bidirectional interactions. These multitissue units drive coordinated neuroimmune responses to local and systemic signals, which represents an important challenge to our current views of mucosal physiology and immune regulation. In this review, we focus on the impact of reciprocal neuroimmune interactions, focusing on the anatomy of neuronal innervation and on the neuronal regulation of immune cells in peripheral tissues. Finally, we shed light on recent studies that explore how neuroimmune interactions maximise sensing and integration of environmental aggressions, modulating immune function in health and disease.

Keywords: Lymphocytes; Mucosal immunology; Neuroimmunology; Neurons.

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