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Review
. 2021 Aug;86(2):e13433.
doi: 10.1111/aji.13433. Epub 2021 May 10.

Uterine natural killer cells and recurrent spontaneous abortion

Yao-Yao Fu  1 , Chun-E Ren  2 , Peng-Yun Qiao  2 , Yu-Han Meng  2
Affiliations
Review

Uterine natural killer cells and recurrent spontaneous abortion

Yao-Yao Fu et al. Am J Reprod Immunol. 2021 Aug.

Abstract

Recurrent spontaneous abortion (RSA), termed as two or more consecutive pregnancy loss is a great problem for some women of childbearing age. A large number of evidence confirm that there may be an immune background of RSA. As a member of the innate immune system, uterine natural killer (uNK) cells account for about 70% of total lymphocytes during pregnancy and play a critical role in the establishment and maintenance of pregnancy. This review mainly introduces the phenotype, origin, receptor, and function of uNK cells to illuminate its relationship with RSA.

Keywords: CD56brightCD56dim; recurrent spontaneous abortion; uterine NK cells.

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References

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