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. 2021 Jun;7(6):479-481.
doi: 10.1016/j.trecan.2021.04.001. Epub 2021 Apr 23.

Asparagine, a Key Metabolite in Cellular Response to Mitochondrial Dysfunction

Yuyang Liu  1 , Kıvanç Birsoy  2
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Asparagine, a Key Metabolite in Cellular Response to Mitochondrial Dysfunction

Yuyang Liu et al. Trends Cancer. 2021 Jun.

Abstract

The mitochondrial electron transport chain (ETC) has been an attractive target for cancer therapy due to its essentiality for tumor growth. Krall et al. found that under ETC dysfunction, a decrease in asparagine limits cancer cell proliferation and activates the integrated stress response, creating a therapeutically exploitable metabolic vulnerability.

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