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. 2020 Jul-Dec;11(2):182-185.
doi: 10.4103/njms.NJMS_50_20. Epub 2020 Dec 16.

Does diagnostic accuracy of surgeon's perception outweigh frozen section analysis in determining intraoperative clear mucosal surgical margins in oral squamous cell carcinoma patients?

Chetan Gupta  1 , Nitin Bhola  1 , Anendd Jadhav  1 , Apoorva Mishra  1 , Pawan Hingnikar  1 , Chinmay Ghavat  1
Affiliations

Does diagnostic accuracy of surgeon's perception outweigh frozen section analysis in determining intraoperative clear mucosal surgical margins in oral squamous cell carcinoma patients?

Chetan Gupta et al. Natl J Maxillofac Surg. 2020 Jul-Dec.

Abstract

Introduction: The lucrativeness of the frozen section for intraoperative margin assessment in head and neck squamous cell carcinoma is debatable till date. The purpose of this study was to evaluate whether surgeon's perception by gross examination (GE) of margin is an alternative to frozen section.

Aim: The aim was to compare the diagnostic accuracy (DA) of surgeon's perception of tumor-free mucosal and soft-tissue surgical margins intraoperatively assessed by GE and frozen section analysis (FSA).

Methodology: A prospective, observational study was conducted on 59 histologically proven cases of oral squamous cell carcinoma. Two hundred and thirty-six mucosal margins were assessed by an experienced surgeon (ES) and thereafter subjected subsequently to FSA. These results were compared with the gold standard histopathology (HPE). The sensitivity (SS), specificity (SP), positive predictor value (PPV), negative predictor value (NPV), and DA of surgeon's perception by GE were calculated and subsequently compared with FSA and HPE using descriptive and inferential statistics.

Results: The SS, SP, PPV, NPV, and DA of ES by GE were 80%, 99.12%, 80%, 99.12%, and 98.30%, respectively when compared to HPE, and the SS of 90%, SP of 98.32%, PPV, NPV, and DA were 69.23%, 99.57%, and 97.98%, respectively when compared with HPE. The results of the surgeon's perception by GE were comparable to the results of FSA.

Conclusion: The study concludes that surgeon's perception by GE is upfront reliable alternative intraoperative method to FSA in places where FS is not available.

Keywords: Frozen section; gross examination; oral squamous cell carcinoma; surgical margin.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Graph 1
Graph 1
The sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of an experienced surgeon by gross examination versus histopathology
Graph 2
Graph 2
The sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of frozen versus histopathology
See this image and copyright information in PMC

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