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Case Reports
. 2021 Apr 5;8(1):46-49.
doi: 10.1080/23320885.2021.1891903.

Splenic marginal zone B-cell lymphoma associated with ruptured breast implants: case report and review of the literature

Mark G Evans  1 , Melissa A Mueller  2 , Frederik Chen  3 , Larry S Nichter  4   5
Affiliations
Case Reports

Splenic marginal zone B-cell lymphoma associated with ruptured breast implants: case report and review of the literature

Mark G Evans et al. Case Reports Plast Surg Hand Surg. .

Abstract

We describe splenomegaly and bilateral grade 2 Baker breast capsular contracture in a woman who had undergone augmentation mammoplasty. This case represents the first documented instance of splenic marginal zone lymphoma, and is among the rare reports of B-cell lymphoma, arising in a patient with breast implants.

Keywords: B-cell lymphoma; Breast implant; augmentation mammoplasty; splenic marginal zone lymphoma; splenomegaly.

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Conflict of interest statement

This case report was not sponsored by any grants or other sources of financial support. The authors declare that there is no conflict of interest regarding the publication of this paper. The patient described in our paper has given written consent to the inclusion of material pertaining to her, has acknowledged that she cannot be identified via the paper, and we have fully anonymized her. All mandatory laboratory health and safety procedures have been complied with in the course of conducting any experimental work reported in our paper.

Figures

Figure 1.
Figure 1.
The patient’s abdominal CT scan demonstrates massive splenomegaly with adjacent abdominal lymphadenopathy.
Figure 2.
Figure 2.
Microscopic examination of the patient’s peripheral blood smeared reveals atypical lymphocytes with villous morphology (A, 1000x magnification). Her bone marrow contained prominent lymphoid aggregates accounting for approximately 20% of the marrow’s cellularity (B, 200x magnification) that were composed of B-cells positive for CD20 by immunohistochemistry (C, 200x magnification).
See this image and copyright information in PMC

References

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    1. Kraemer DM, Tony HP, Gattenlohner S, et al. Lymphoplasmacytic lymphoma in a patient with leaking silicone implant. Haematologica. 2004;89(4):ELT01. - PubMed
    1. Nichter LS, Mueller MA, Burns RG, et al. First report of nodal marginal zone B-cell lymphoma associated with breast implants. Plast Reconstr Surg. 2012;129(3):576e–578e. - PubMed
    1. Moling O, Piccin A, Tauber M, et al. Intravascular large B-cell lymphoma associated with silicone breast implant, HLA-DRB1*11:01, and HLA-DQB1*03:01 manifesting as macrophage activation syndrome and with severe neurological symptoms: a case report. J Med Case Rep. 2016;10(1):254. - PMC - PubMed
    1. Smith BK, Gray SS.. Large B-cell lymphoma occurring in a breast implant capsule. Plast Reconstr Surg. 2014; 134(4):670e–671e. - PubMed

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