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. 2021 Apr 7:26:100992.
doi: 10.1016/j.bbrep.2021.100992. eCollection 2021 Jul.

Omega-3 effects on electrocorticographic patterns of adult Wistar rats exposed to ionizing radiation

H G I F Lima  1 , I M S S Lopes  2 , A P B Oliveira  3 , E V L Costa  1 , L A A Aguiar  1 , B P A Lindoso  1 , M C O Silva  1 , J E S Silva  1 , R A Nogueira  1
Affiliations

Omega-3 effects on electrocorticographic patterns of adult Wistar rats exposed to ionizing radiation

H G I F Lima et al. Biochem Biophys Rep. .

Abstract

This study aimed to assess the effect of supplementation with omega-3 in Wistar rats exposed to ionizing radiation in a dose of 18 Gy on the cortical electrical activity, using mathematical methods such as the power spectrum (PS) and the detrended fluctuation analysis (DFA) in the evaluation of the electrocorticogram (ECoG) record. The PS analysis showed that in non-irradiated animals but supplemented with omega-3 there was a decrease in the power of the beta rhythm, while the DFA applied to different frequency ranges of the ECoG showed a significant increase in the long-range correlation only for the theta wave when compared with non-supplemented animals. In the evaluation of the radiation effect through the PS, an increase in the power of the theta rhythm was observed in both groups (non-supplemented and supplemented animals) only when they were evaluated one week after irradiation. The DFA method also showed difference in this wave. The PS and DFA methods applied to the ECoG record allowed a quantitative analysis of the cortical electrical activity in rats in response to the omega-3 effects, ionizing radiation, or both.

Keywords: Brain electrical activity; Head–neck irradiation; Polyunsaturated fatty acid.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Image 1
Graphical abstract
Fig. 1
Fig. 1
α-DFA values obtained to the total ECoG and to different brain rhythms: delta (0.5–4 Hz), theta (4–8 Hz), alpha (8–12 Hz) and beta (16–30 Hz) of the non-supplemented (NSG) and supplemented (SG) groups evaluated 24 h before radiation exposure. Values with (*) represent a significant difference between groups (p < 0.05). Unpaired t-test.
Fig. 2
Fig. 2
α-DFA values obtained to the total ECoG and different brain rhythms: delta (0.5–4 Hz), theta (4–8 Hz), alpha (8–12 Hz) and beta (16–30 Hz) of the non-supplemented group (NSG) evaluated at 24 h before irradiation (M1), 24 h (M2) and one week (M3) after exposure to ionizing radiation. No significant difference was observed (p > 0.05). ANOVA test.
Fig. 3
Fig. 3
α-DFA values obtained to the total ECoG and to different brain rhythms: delta (0.5–4 Hz), theta (4–8 Hz), alpha (8–12 Hz) and beta (16–30 Hz) from the supplement group (SG) evaluated 24 h before, 24 h, and one week after irradiation (M1, M2 and M3, respectively). Values with (*) represent a statistically significant difference in the group concerning the moment of evaluation (p < 0.05). Kruskal-Wallis and Dunn's tests to total ECoG, alpha, and theta rhythms. ANOVA with Tukey's tests to delta and beta rhythms.
Fig. 4
Fig. 4
α-DFA values obtained to the total ECoG and to different brain rhythms: delta (0.5–4 Hz), theta (4–8 Hz), alpha (8–12 Hz), and beta (16–30 Hz) of the non-supplemented (NSG) and supplemented (SG) groups evaluated 24 h (M2) and one week after radiation exposure (M3). Values with (*) represent a significant difference between groups (p < 0.05). Unpaired t-test.
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