Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Feb 25;38(1):154-160.
doi: 10.7507/1001-5515.202011038.

[Evaluation on monitoring effect of the electronic vaccine vial monitor label]

[Article in Chinese]
Xiaofang Chen  1 , Jianzhong Liu  2 , Qianyu Yao  3 , Xianyi Chen  2
Affiliations

[Evaluation on monitoring effect of the electronic vaccine vial monitor label]

[Article in Chinese]
Xiaofang Chen et al. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. .

Abstract
in English, Chinese

The cold chain safety of vaccines is a global issue. The electronic vaccine vial monitor (eVVM) label can monitor the temperature of vaccines in real time and provide "early warning" prompts. In order to comprehensively evaluate the monitoring efficiency of eVVM, this study selected 75 eVVM labels and distributed them with a total of 600 vaccine vial monitor (VVM) labels of four different types in different experimental environment (2-8℃, -20℃ and 40℃), and used a temperature recorder as "gold standard". The results showed that the accuracy of the eVVM labels and VVM labels in high temperature environment was as same as that of the temperature recorder ( P = 0.195). The accuracy of low temperature anomalies report and high temperature anomalies report of eVVM labels was 100%, which was better than those reported by VVM labels. Therefore, eVVM labels have high monitoring accuracy, which is suitable not only for ordinary environments, but also for severe temperature environments. It should be helpful for the improvement of the efficiency and accuracy of cold chain monitoring.

疫苗的冷链安全为全球性问题，电子疫苗热敏感标签（eVVM）可对疫苗温度进行实时监控，并进行“预警”提示。为综合评价 eVVM 的监测效能，本研究在不同产品批次中随机抽取 75 个 eVVM 标签，将其与四种不同类型共 600 个疫苗温度指示标签（VVM）平均分配到不同的实验环境中（2～8℃、−20℃ 以及 40℃），采用温度记录仪作为对照。结果显示，eVVM 标签、VVM 标签在高温温度监测方面的精确度与温度记录仪具有很好的一致性（ P = 0.195），且 eVVM 标签在低温异常和高温异常的正确率均为 100%，优于 VVM 标签。因此，我们认为 eVVM 标签有较高的精确度，对于进一步提高冷链的监测效率及准确度均具有良好的应用前景。.

Keywords: label; thermal sensitivity; vaccine.

PubMed Disclaimer

Figures

1
1
Internal structure of chip 芯片内部结构图
2
2
Product diagram 产品示意图
3
3
Scanning interface of eVVM label supporting software eVVM 配套软件扫描界面
4
4
Color change diagram of VVM label VVM 标签变色示意图
5
5
Monitoring results of eVVM labels and temperature recorder (2–8℃) 2～8℃ 环境下 eVVM 标签与温度记录仪监测结果的曲线图
6
6
Monitoring results of eVVM labels and temperature recorder (−20℃) −20℃ 环境下 eVVM 标签与温度记录仪监测结果的曲线图
7
7
Monitoring results of eVVM labels and temperature recorder (40℃) 40℃ 环境下 eVVM 标签与温度记录仪监测结果的曲线图
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. 王月丹, 初明 疫苗接种安全问题的产生及其科学应对措施. 中国药物评价. 2014;31(1):56–60. doi: 10.3969/j.issn.2095-3593.2014.01.018. [王月丹, 初明. 疫苗接种安全问题的产生及其科学应对措施. 中国药物评价, 2014, 31(1): 56-60.] - DOI
    1. 姜晓飞 预防接种信息管理系统的实施及应用进展. 中国疫苗和免疫. 2014;20(1):79–84. [姜晓飞. 预防接种信息管理系统的实施及应用进展. 中国疫苗和免疫, 2014, 20(1): 79-84.]
    1. 应徐颉, 刘琼, 张明胜, 等 我国疫苗冷链管理现状及发展展望. 中国现代应用药学. 2020;37(5):636–640. [应徐颉, 刘琼, 张明胜, 等. 我国疫苗冷链管理现状及发展展望. 中国现代应用药学, 2020, 37(5): 636-640.]
    1. 田素霞 疫苗冷链运输过程中的质量风险管理研究. 中国当代医药. 2018;25(17):164–168. doi: 10.3969/j.issn.1674-4721.2018.17.050. [田素霞. 疫苗冷链运输过程中的质量风险管理研究. 中国当代医药, 2018, 25(17): 164-168.] - DOI
    1. 余文周, 王富珍, 温宁, 等 中国深化医疗改革十年免疫规划助力全民健康. 中国疫苗和免疫. 2020;26(5):602–606. [余文周, 王富珍, 温宁, 等. 中国深化医疗改革十年免疫规划助力全民健康. 中国疫苗和免疫, 2020, 26(5): 602-606.]

LinkOut - more resources