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. 2021 Oct 4;25(4):592-600.
doi: 10.5935/1518-0557.20210013.

Current markers for infertility in men

Jéssica Alves Magalhães  1 , Larissa Sousa Ribeiro  1   2 , João Paulo Arcelino Rego  2 , Claudia Roberta de Andrade  1
Affiliations

Current markers for infertility in men

Jéssica Alves Magalhães et al. JBRA Assist Reprod. .

Abstract

Male infertility accounts for about 30% of the causes of couple infertility and has become a public health concern. Male infertility may be caused by several factors occurring in isolation or association with several complex syndromes. Despite the importance of semen analysis in the initial investigation of infertility, it has been estimated that 15% of infertile men present normal sperm, a proportion that calls for additional tests to further investigate cases of infertility and accurately determine the factors that alter ejaculate quality. In addition to semen analysis parameters, genetics has been drawing attention. The incorporation of genetic diagnostic methods in the routine practice of andrology laboratories is an important step to further improve assisted reproductive technologies. The present study described the current status of the main methods used in male infertility investigation.

Keywords: diagnostic methods; male infertility; proteomics; semen quality.

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Conflict of interest statement

CONFLICT OF INTEREST

The authors have no conflict of interest to declare.

Figures

Figure 1
Figure 1
Problems in the number of spermatozoa and correlations with genetic abnormalities. There is a negative correlation between the number of spermatozoa and genetic abnormalities (Adapted from Krausz & Riera-Escamilla, 2018).
See this image and copyright information in PMC

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