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Review
. 2021 Jun 1;34(3):264-271.
doi: 10.1097/QCO.0000000000000729.

Arboviral central nervous system infections

Jonathan S Schultz  1 , Hadrian Sparks  2 , J David Beckham  1   2   3
Affiliations
Review

Arboviral central nervous system infections

Jonathan S Schultz et al. Curr Opin Infect Dis. .

Abstract

Purpose of review: This review provides an overview of arthropod-borne virus (arbovirus) infections that are important causes of human neurological infections world-wide. As many of the individual viruses in a specific genus or family cause overlapping clinical syndromes, this review discusses important viruses in groups to highlight some of the similarities and differences in groups of neuroinvasive arbovirus infections.

Recent findings: Arboviruses that cause neurological infections in humans continue to emerge and distribute to new regions. The geographic range of the vectors, the hosts and subsequent arbovirus infections in humans continues to expand and evolve. As emerging arboviruses move into new geographic regions, it is important to examine the associated epidemiological and clinical impacts of these infections as they enter new populations.

Summary: Arboviruses from the Flaviviridae, Togaviridae and Bunyaviridae families continue to emerge and spread into new regions. The arboviruses within these virus families cause characteristic neuroinvasive diseases in human populations. A complete understanding of the epidemiological and clinical features of the neuroinvasive arboviruses is important such that these pathogens can be recognized and diagnosed in humans as they emerge. Ongoing research to develop rapid, accurate diagnostics, therapeutic options and vaccines for these pathogens is needed to address future outbreaks of disease in human populations.

Trial registration: ClinicalTrials.gov NCT00584805.

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