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Evaluating Differences in Whole Blood, Serum, and Urine Screening Tests for Zika Virus, Puerto Rico, USA, 2016

Asher Y Rosinger et al. Emerg Infect Dis. 2021 May.

Abstract

We evaluated nucleic acid amplification testing (NAAT) for Zika virus on whole-blood specimens compared with NAAT on serum and urine specimens among asymptomatic pregnant women during the 2015-2016 Puerto Rico Zika outbreak. Using NAAT, more infections were detected in serum and urine than in whole blood specimens.

Keywords: NAAT; PCR; Puerto Rico; United States; Zika virus; mosquito-borne diseases; mosquitos; nucleic acid amplification testing; outbreak; pregnancy; vector-borne diseases; viruses; whole blood; zoonoses.

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Figures

Figure
Figure
Comparison of positive NAAT results by specimen type for Zika virus infection among asymptomatic pregnant women, Puerto Rico, USA, October 1–November 4, 2016. NAAT, nucleic acid amplification testing.
See this image and copyright information in PMC

References

    1. Musso D, Ko AI, Baud D. Zika virus infection—after the pandemic. N Engl J Med. 2019;381:1444–57. 10.1056/NEJMra1808246 - DOI - PubMed
    1. Centers for Disease Control and Prevention. Testing guidance: new Zika and dengue testing guidance (updated November 2019) [cited 2020 Jul 14]. https://www.cdc.gov/zika/hc-providers/testing-guidance.html
    1. Sharp TM, Fischer M, Muñoz-Jordán JL, Paz-Bailey G, Staples JE, Gregory CJ, et al. Dengue and Zika virus diagnostic testing for patients with a clinically compatible illness and risk for infection with both viruses. MMWR Recomm Rep. 2019;68:1–10. 10.15585/mmwr.rr6801a1 - DOI - PMC - PubMed
    1. Oduyebo T, Polen KD, Walke HT, Reagan-Steiner S, Lathrop E, Rabe IB, et al. Update: interim guidance for health care providers caring for pregnant women with possible Zika virus exposure—United States (including U.S. territories), July 2017. MMWR Morb Mortal Wkly Rep. 2017;66:781–93. 10.15585/mmwr.mm6629e1 - DOI - PMC - PubMed
    1. Chua A, Prat I, Nuebling CM, Wood D, Moussy F. Update on Zika diagnostic tests and WHO’s related activities. PLoS Negl Trop Dis. 2017;11:e0005269. 10.1371/journal.pntd.0005269 - DOI - PMC - PubMed