Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2021 Aug 1;204(3):245-247.
doi: 10.1164/rccm.202104-0844ED.

Postextubation Respiratory Support: Of Clinical Trials and Clinical Decisions

Ewan C Goligher  1   2   3 , Oscar Peñuelas  4   5
Affiliations
Editorial

Postextubation Respiratory Support: Of Clinical Trials and Clinical Decisions

Ewan C Goligher et al. Am J Respir Crit Care Med. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Average treatment effect (dashed line) and individual treatment effect (points) in a theoretical population of patients enrolled in a trial. Treatment is appropriate in patients with a favorable individual treatment effect (blue shaded region). Designing trials with the goal of learning individual treatment effect will maximize the relevance of clinical trials to clinical decisions.
See this image and copyright information in PMC

Comment on

References

    1. Peñuelas O, Muriel A, Abraira V, Frutos-Vivar F, Mancebo J, Raymondos K, et al. Inter-country variability over time in the mortality of mechanically ventilated patients. Intensive Care Med. 2020;46:444–453. - PMC - PubMed
    1. Angus DC. Optimizing the trade-off between learning and doing in a pandemic. JAMA. 2020;323:1895–1896. - PubMed
    1. Goligher EC, Zampieri F, Calfee CS, Seymour CW. A manifesto for the future of ICU trials. Crit Care. 2020;24:686. - PMC - PubMed
    1. Casey JD, Vaughan EM, Lloyd BD, Billas PA, Jackson KE, Hall EJ, et al. Vanderbilt Learning Healthcare System and the Pragmatic Critical Care Research Group. Protocolized postextubation respiratory support to prevent reintubation: a randomized clinical trial. Am J Respir Crit Care Med. 2021;204 - PMC - PubMed
    1. Granton D, Chaudhuri D, Wang D, Einav S, Helviz Y, Mauri T, et al. High-flow nasal cannula compared with conventional oxygen therapy or noninvasive ventilation immediately postextubation: a systematic review and meta-analysis. Crit Care Med. 2020;48:e1129–e1136. - PubMed