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1 Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
2 China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
3 Neurology, Marcus Stroke and Neuroscience Center, Grady Memorial Hospital, Emory University School of Medicine, Atlanta, Georgia, USA.
4 Neurosurgery, Cleveland Clinic Martin Health, Port St Lucie, Florida, USA.
5 Cooper Neurologic Institute, Cooper University Hospital, Camden, New Jersey, USA.
6 Neurology, Cooper Medical School of Rowan University, Camden, New Jersey, USA.
7 China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China yongjunwang@ncrcnd.org.cn.
1 Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
2 China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
3 Neurology, Marcus Stroke and Neuroscience Center, Grady Memorial Hospital, Emory University School of Medicine, Atlanta, Georgia, USA.
4 Neurosurgery, Cleveland Clinic Martin Health, Port St Lucie, Florida, USA.
5 Cooper Neurologic Institute, Cooper University Hospital, Camden, New Jersey, USA.
6 Neurology, Cooper Medical School of Rowan University, Camden, New Jersey, USA.
7 China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China yongjunwang@ncrcnd.org.cn.
Meta-analysis of the efficacy and safety outcomes of three randomised trials. (A) 1.1…
Figure 1
Meta-analysis of the efficacy and safety outcomes of three randomised trials. (A) 1.1 mRS 0–2; 1.2 successful recanalisation (eTICI ≥2b in the DIRECT-MT and DEVT, and TICI ≥2b in the SKIP; (B) 1.3 mRS at 90 days; (C) 2.1 death; 2.2 sICH (Heidelberg criteria in the DIRECT-MT; NINDS criteria in the DEVT and the SKIP. dEVT, direct EVT; eTICI, expanded Thrombolysis in Cerebral Infarction; EVT, endovascular thrombectomy; IVT, intravenous thrombolysis; mRS, modified Rankin Scale; NINDS, National Institute of Neurological Disorders and Stroke; sICH, symptomatic intracerebral haemorrhage.
Yang P, Zhang Y, Zhang L, et al. . Endovascular thrombectomy with or without intravenous alteplase in acute stroke. N Engl J Med 2020;382:1981–93. 10.1056/NEJMoa2001123
-
DOI
-
PubMed
Zi W, Qiu Z, Li F, et al. . Effect of endovascular treatment alone vs intravenous alteplase plus endovascular treatment on functional independence in patients with acute ischemic stroke: the devt randomized clinical trial. JAMA 2021;325:234–43. 10.1001/jama.2020.23523
-
DOI
-
PMC
-
PubMed
Suzuki K, Matsumaru Y, Takeuchi M, et al. . Effect of mechanical thrombectomy without vs with intravenous thrombolysis on functional outcome among patients with acute ischemic stroke: the SKIP randomized clinical trial. JAMA 2021;325:244–53. 10.1001/jama.2020.23522
-
DOI
-
PMC
-
PubMed
Anderson CS, Robinson T, Lindley RI, et al. . Low-dose versus standard-dose intravenous alteplase in acute ischemic stroke. N Engl J Med 2016;374:2313–23. 10.1056/NEJMoa1515510
-
DOI
-
PubMed
Nogueira RG, Tsivgoulis G. Large vessel occlusion strokes after the direct-mt and SKIP trials: is the alteplase syringe half empty or half full? Stroke 2020;51:3182–6. 10.1161/STROKEAHA.120.030796
-
DOI
-
PubMed