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. 2021 May;38(5):1045-1053.
doi: 10.1007/s10815-021-02078-4. Epub 2021 Apr 26.

Utilization of preimplantation genetic testing in the USA

Kaitlyn Roche  1 , Catherine Racowsky  2 , Joyce Harper  3
Affiliations

Utilization of preimplantation genetic testing in the USA

Kaitlyn Roche et al. J Assist Reprod Genet. 2021 May.

Abstract

Purpose: To evaluate the use of preimplantation genetic testing (PGT) and live birth rates (LBR) in the USA from 2014 to 2017 and to understand how PGT is being used at a clinic and state level.

Methods: This study accessed SART data for 2014 to 2017 to determine LBR and the CDC for years 2016 and 2017 to identify PGT usage. Primary cycles included only the first embryo transfer within 1 year of an oocyte retrieval; subsequent cycles included transfers occurring after the first transfer or beyond 1 year of oocyte retrieval.

Results: In the SART data, the number of primary PGT cycles showed a significant monotonic annual increase from 18,805 in 2014 to 54,442 in 2017 (P = 0.042) and subsequent PGT cycles in these years increased from 2946 to 14,361 (P = 0.01). There was a significant difference in primary PGT cycle use by age, where younger women had a greater percentage of PGT treatment cycles than older women. In both PGT and non-PGT cycles, the LBR per oocyte retrieval decreased significantly from 2014 to 2017 (P<0001) and younger women had a significantly higher LBR per oocyte retrieval compared to older women (P < 0.001). The CDC data revealed that in 2016, just 53 (11.4%) clinics used PGT for more than 50% of their cycles, which increased to 99 (21.4%) clinics in 2017 (P< 0.001).

Conclusions: A growing number of US clinics are offering PGT to their patients. These findings support re-evaluation of the application for PGT.

Keywords: CDC; PGT; PGT-A; Preimplantation diagnosis; SART.

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Conflict of interest statement

JH is partner of the Embryology and PGD Academy which offers training and online education in PGD. JH is occasionally paid by various companies to give lectures.

Figures

Fig. 1
Fig. 1
The LBR for non-PGT and PGT per oocyte retrieval and transfer procedure from 2014
Fig. 2
Fig. 2
a The LBR per oocyte retrieval for primary non-PGT and PGT cycles stratified by patient age from 2014 to 2017. b LBR for subsequent non-PGT and PGT cycles from 2014 to 2017
Fig. 3
Fig. 3
Comparison of PGT usage by US clinics in 2016 compared with 2017. Numbers above the bars are the number of clinics
See this image and copyright information in PMC

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References

    1. Harper JC, Handyside AH. The current status of preimplantation diagnosis. Curr Obstet Gynaecol. 1994;4:143–149. doi: 10.1016/0957-5847(94)90033-7. - DOI
    1. Harper JC. Preimplantation diagnosis of inherited disease by embryo biopsy. An update of the world figures. J Assit Reprod Genet. 1996;13(2):90–4. - PubMed
    1. Harper JC, Wilton L, Traeger-Synodinos J, Goossens V, Moutou C, SenGupta SB, Pehlivan Budak T, Renwick P, De Rycke M, Geraedts JPM, Harton G. The ESHRE PGD Consortium: 10 years of data collection. Hum Reprod Update. 2012;18:234–247. doi: 10.1093/humupd/dmr052. - DOI - PubMed
    1. De Rycke M, Goossens V, Kokkali G, Meijer-Hoogeveen M, Coonen E, Moutou C. ESHRE PGD Consortium data collection XIV–XV: cycles from January 2011 to December 2012 with pregnancy follow-up to October 2013†. Hum Reprod. 2017;32:1974–1994. doi: 10.1093/humrep/dex265. - DOI - PubMed
    1. Zegers-Hochschild F, Adamson GD, de Mouzon J, Ishihara O, Mansour R, Nygren K, Sullivan E, van der Poel S. The International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary on ART Terminology, 2009. Hum Reprod. 2009;24:2683–2687. doi: 10.1093/humrep/dep343. - DOI - PubMed