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. 2021 Apr 26;36(16):e104.
doi: 10.3346/jkms.2021.36.e104.

A Longitudinal Study of Adult Patients with Staphylococcus aureus Bacteremia over 11 Years in Korea

Seong Ho Choi #  1 , Jeongsoo Lee #  2 , Jiwon Jung  2 , Eun Sil Kim  3   4 , Min Jae Kim  2 , Yong Pil Chong  2 , Sung Han Kim  2 , Sang Oh Lee  2 , Sang Ho Choi  2 , Jun Hee Woo  2 , Yang Soo Kim  2   3   5
Affiliations

A Longitudinal Study of Adult Patients with Staphylococcus aureus Bacteremia over 11 Years in Korea

Seong Ho Choi et al. J Korean Med Sci. .

Abstract

Background: The temporal changes in the Staphylococcus aureus genotypes causing S. aureus bacteremia (SAB) and the corresponding clinical changes over the last decade in South Korea are rarely investigated.

Methods: A longitudinal study of adult SAB patients was conducted in a large referral hospital in Seoul, South Korea. Adult monomicrobial SAB patients were enrolled between August 2008 and December 2018. Genotyping was performed by multilocus sequence typing (MLST) and staphylococcal protein A (spa) typing. Trends in changes were identified by linear regression analysis.

Results: Of 1782 adult SAB patients, the blood isolates of 1,778 (99.8%) and 1,634 (91.7%) were determined to be MLST and spa type, respectively. ST5 (-2.626%/year) and ST239 (-0.354%/year) decreased during the study period (P < 0.001 for both), but ST72 (2.009%/yr)-and ST8 (0.567%/yr) increased (P < 0.001 for both). The most common genotype was changed from ST5 in 2008 (44.9%) to ST72 in 2018 (36.3%). Panton-Valentine leukocidin-positive spa-t008-MRSA (USA300) was found in 28.6%. Central venous catheter (CVC)-related SAB (-2.440%/yr) and persistent SAB (-1.016%/yr) decreased, but mortality and recurrence rates were unchanged.

Conclusion: Over the last decade, the hospital clones ST5 and ST239 have been replaced by community genotype ST72. This was associated with decreased CVC-related and persistent SAB. Increased USA300 was observed in community and hospital settings. Further research is required to identify the reasons for the ST72 epidemic and predict the impending epidemic of ST8 strains, including USA300.

Keywords: Bacteremia; Genotype; Multilocus Sequence Typing; Staphylococcus aureus.

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Conflict of interest statement

The authors have no potential conflicts of interest to disclose.

Figures

Fig. 1
Fig. 1. Longitudinal change of multilocus sequence typing ST proportion in adult patients with Staphylococcus aureus bacteremia.
Fig. 2
Fig. 2. Longitudinal change of multilocus sequence typing ST proportion in adult patients with methicillin-resistant Staphylococcus aureus bacteremia.
Fig. 3
Fig. 3. Longitudinal change of multilocus sequence typing ST proportion in adult patients with methicillin-susceptible Staphylococcus aureus bacteremia.
See this image and copyright information in PMC

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References

    1. Holland TL, Fowler VG., Jr Epidemiology of Staphylococcus aureus bacteremia in adults. [Updated 2019]. [Accessed November 24, 2019]. https://www.uptodate.com.
    1. Lakhundi S, Zhang K. Methicillin-resistant Staphylococcus aureus: molecular characterization, evolution, and epidemiology. Clin Microbiol Rev. 2018;31(4):e00020–18. - PMC - PubMed
    1. Kirby WM. Extraction of a highly potent penicillin inactivator from penicillin resistant staphylococci. Science. 1944;99(2579):452–453. - PubMed
    1. Lowy FD. Staphylococcus aureus infections. N Engl J Med. 1998;339(8):520–532. - PubMed
    1. Seybold U, Kourbatova EV, Johnson JG, Halvosa SJ, Wang YF, King MD, et al. Emergence of community-associated methicillin-resistant Staphylococcus aureus USA300 genotype as a major cause of health care-associated blood stream infections. Clin Infect Dis. 2006;42(5):647–656. - PubMed

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