Comparative Study
[Quantitative estimation of synaptic acetylcholinesterase inhibition with galanthamine using parameters of miniature endplate currents]
[Article in
Russian]
- PMID: 3390582
Item in Clipboard
Comparative Study
[Quantitative estimation of synaptic acetylcholinesterase inhibition with galanthamine using parameters of miniature endplate currents]
[Article in
Russian]
Biull Eksp Biol Med.
1988 Jun.
Abstract
Miniature end-plate currents (MEPC) were recorded in voltage clamped muscle fibers of the rat diaphragm at different degrees of acetylcholinesterase (AChE) inhibition with galanthamine. A model has been suggested connecting the increase in MEPC amplitude with the concentration of a competitive reversible AChE inhibitor. Using the model suggested, the changes in the junctional AChE activity inhibited with different concentrations of galanthamine were estimated. The calculated value of the inhibitory galanthamine constant is 2.8 X 10(-7) M.
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