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. 1988 Jul;72(1):328-34.

Molecular cloning of the cDNA for human erythrocyte beta-spectrin

J C Winkelmann  1 , T L Leto, P C Watkins, R Eddy, T B Shows, A J Linnenbach, K E Sahr, N Kathuria, V T Marchesi, B G Forget
Affiliations
  • PMID: 3390609
Free article

Molecular cloning of the cDNA for human erythrocyte beta-spectrin

J C Winkelmann et al. Blood. 1988 Jul.
Free article

Abstract

Overlapping cDNA clones, totaling 3.3 kilobases (kb) in length, which encode over 50% of the human erythrocyte beta-spectrin subunit, were isolated by antibody screening of a lambda gt11 expression library constructed from human fetal liver mRNA. The amino acid sequence of the C-terminus of beta-spectrin was derived. The size of beta-spectrin mRNA in human erythroleukemia cells was found to be 7.5 kb. Erythrocyte beta-spectrin is encoded by a gene located on human chromosome 14, as determined by cDNA hybridization to human X mouse somatic cell hybrids.

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