Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Apr 27;70(8):1419-1425.
doi: 10.1136/gutjnl-2019-319807. Online ahead of print.

Therapeutic potential of microbial modulation in pancreatic cancer

Affiliations

Therapeutic potential of microbial modulation in pancreatic cancer

Vidhi Chandra et al. Gut. .
No abstract available

Keywords: immune response; intestinal microbiology; pancreatic cancer.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Overview of clinical FMT trials by status (A), clinical phase (B), delivery mode (C) and cancer (D) reported in ClinicalTrials.gov as of September 2020. autoimm, autoimmune; FMT, faecal microbial transplant; inflamm, inflammatory.
Figure 2
Figure 2
Diagram showing different approaches to microbiota modulation for cancer treatment. The overall goal is to shift the tumour microenvironment from an immunosuppressive to an immune-activated state. FMT, faecal microbial transplant; MDSC, myeloid-derived suppressor cell; TH1, type I helper; Treg, regulatory T cell.

References

    1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin 2020;70:7–30. 10.3322/caac.21590 - DOI - PubMed
    1. Rhim AD, Mirek ET, Aiello NM, et al. . Emt and dissemination precede pancreatic tumor formation. Cell 2012;148:349–61. 10.1016/j.cell.2011.11.025 - DOI - PMC - PubMed
    1. Conroy T, Desseigne F, Ychou M, et al. . Folfirinox versus gemcitabine for metastatic pancreatic cancer. N Engl J Med 2011;364:1817–25. 10.1056/NEJMoa1011923 - DOI - PubMed
    1. Von Hoff DD, Ervin T, Arena FP, et al. . Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med 2013;369:1691–703. 10.1056/NEJMoa1304369 - DOI - PMC - PubMed
    1. Neoptolemos JP, Stocken DD, Bassi C, et al. . Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection: a randomized controlled trial. JAMA 2010;304:1073–81. 10.1001/jama.2010.1275 - DOI - PubMed