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Editorial
. 2021 May:41:100884.
doi: 10.1016/j.nmni.2021.100884. Epub 2021 Apr 23.

Is the heparin-induced thrombocytopenia-like syndrome associated with ChAdOx vaccine related to the vaccine itself or to an autoimmune reaction to severe acute respiratory syndrome 2 coronavirus: insights and implications from previous reports in infected cases?

A AbdelMassih  1   2 , R Hozaien  3 , M El Shershaby  3 , A Kamel  3 , H-A Ismail  3 , R Fouda  4
Affiliations
Editorial

Is the heparin-induced thrombocytopenia-like syndrome associated with ChAdOx vaccine related to the vaccine itself or to an autoimmune reaction to severe acute respiratory syndrome 2 coronavirus: insights and implications from previous reports in infected cases?

A AbdelMassih et al. New Microbes New Infect. 2021 May.

Abstract

Prothrombotic states, similar to heparin-induced thrombocytopenia (HIT) in recipients of the ChAdOx vaccine, sounded alarm bells internationally. Equivalent episodes of HIT were detailed in several case reports of coronavirus disease 2019. This suggests a common pathogenesis and warrants a shift in the management of implicated cases.

Keywords: Adenovirus mediated vaccines; COVID-19; ChAdOx vaccine; PF4 antibodies; avoidance of heparin related anticoagulants; thrombotic thrombocytopenic purpura.

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Figures

Fig. 1
Fig. 1
Lessons to learn from the HIT-like syndrome observed in SARS-CoV-2 infection and vaccination. Abbreviations: COVID-19, coronavirus disease 2019; HIT, heparin-induced thrombocytopenia; PF-4, platelet factor 4; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.
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