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Observational Study
. 2021 Nov;40(11):2437-2442.
doi: 10.1007/s10096-021-04245-y. Epub 2021 Apr 28.

Characteristics and outcome of varicella-zoster virus central nervous system infections in adults

A Le Bot #  1 , A Ballerie #  2 , C Pronier  3 , F Bénézit  1 , F Reizine  1 , M Tas  4 , P Jégo  2 , M Revest  1 , Y Le Tulzo  1 , P Fillâtre  5 , Pierre Tattevin  6
Affiliations
Observational Study

Characteristics and outcome of varicella-zoster virus central nervous system infections in adults

A Le Bot et al. Eur J Clin Microbiol Infect Dis. 2021 Nov.

Abstract

We conducted an observational retrospective study of all adults hospitalized for documented varicella-zoster virus (VZV) meningitis or encephalitis during years 2000-2015 in one referral centre. Thirty-six patients (21 males, 15 females) were included, with meningitis (n = 21), or meningoencephalitis (n = 15). Median age was 51 years [interquartile range, 35-76], and 6 patients (17%) were immunocompromised. Aciclovir was started in 32 patients (89%), with a median dose of 11 mg/kg/8 h [10-15]. No patient died, but 12 (33%) had neurological sequelae at discharge. Age was the only variable associated with adverse outcome (OR 1.98 [1.17-3.35] per 10-year increment, P = 0.011).

Keywords: Encephalitis; Meningitis; Prognosis; Varicella-zoster virus.

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