Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 May;12(5):981-1001.
doi: 10.1007/s13346-021-00988-5. Epub 2021 Apr 28.

Topical delivery of salicylates

Soo Chin Yeoh  1 , Choon Fu Goh  2
Affiliations
Review

Topical delivery of salicylates

Soo Chin Yeoh et al. Drug Deliv Transl Res. 2022 May.

Abstract

Salicylates have a long history of use for pain relief. Salicylic acid and methyl salicylate are among the widely used topical salicylates namely for keratolytic and anti-inflammatory actions, respectively. The current review summarises both passive and active strategies, including emerging technologies employed to enhance skin permeation of these two salicylate compounds. The formulation design of topical salicylic acid targets the drug retention in and on the skin based on the different indications including keratolytic, antibacterial and photoprotective actions, while the investigations of topical delivery strategies for methyl salicylate are limited. The pharmacokinetics and metabolisms of both salicylate compounds are discussed. The current overview and future perspectives of the topical delivery strategies are also highlighted for translational considerations of formulation designs.

Keywords: Formulation; Salicylates; Skin; Skin permeation; Topical.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Levesque H, Lafont O. Aspirin throughout the ages: a historical review. Rev Med Interne. 2000;21:8–17. https://doi.org/10.1016/s0248-8663(00)88720-2 . - DOI
    1. Gross M, Greenberg LA, Haggard HW. The salicylates, a critical bibliographic review. Anesth Analg. 1948;27(6):137–8. https://doi.org/10.1093/ajcp/18.12.987a . - DOI
    1. Norn S, Permin H, Kruse PR, Kruse E. From willow bark to acetylsalicylic acid. Dansk Medicinhistorisk Arbog. 2009;37:79–98. - PubMed
    1. Desborough MJ, Keeling DM. The aspirin story–from willow to wonder drug. Br J Haematol. 2017;177(5):674–83. https://doi.org/10.1111/bjh.14520 . - DOI - PubMed
    1. Needs CJ, Brooks PM. Clinical pharmacokinetics of the salicylates. Clin Pharmacokinet. 1985;10(2):164–77. https://doi.org/10.2165/00003088-198510020-00004 . - DOI - PubMed

Publication types

LinkOut - more resources