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. 2021 Jul;30(4):398-405.
doi: 10.1111/ajad.13170. Epub 2021 Apr 28.

Development and Feasibility Study of an Addiction-Focused Phenotyping Assessment Battery

Lori A Keyser-Marcus  1   2 , Tatiana Ramey  3 , James Bjork  1   2 , Amanda Adams  2 , F Gerard Moeller  1   2
Affiliations

Development and Feasibility Study of an Addiction-Focused Phenotyping Assessment Battery

Lori A Keyser-Marcus et al. Am J Addict. 2021 Jul.

Abstract

Background and objectives: Current methods of classifying individuals with substance use disorder (SUD) result in vast heterogeneity among persons within a given diagnosis. These approaches, while clinically allowing for distinctions between patient groups, are less than ideal when attempting to recruit a neurobehaviorally defined subset of subjects into clinical trials. To address this gap, alternative strategies have been proposed, including behavioral phenotyping. The NIDA Phenotyping Assessment Battery (PhAB) is a modular package of assessments and neurocognitive tasks that was developed for use in clinical trials. The goal of the present study is to assess the feasibility of the NIDA PhAB with regard to ease of administration and time burden.

Methods: Healthy controls, persons with cocaine use disorder (CocUD), opioid use disorder (OUD), cannabis use disorder (CanUD), and combined opioid and cocaine use disorder (OCUD) were recruited from various sources (N = 595). Participants completed screening and one to three assessment visits. Time to complete the measures was recorded and a satisfaction interview was administered.

Results: Of the participants enrolled, 381 were deemed eligible. The majority of eligible participants (83%) completed all assessments. The average completion time was 3 hours. High participant satisfaction ratings were noted, with over 90% of participants endorsing a willingness to participate in a similar study and recommend the study to others. CONCLUSION AND SCIENTIFIC SIGNIFICANCE: These findings corroborate the ease with which the PhAB may be easily incorporated into a study assessment visit without undue participant burden. The PhAB is an efficient method for behavioral phenotyping in addiction clinical trials. (Am J Addict 2021;00:00-00).

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Figures

Figure 1.
Figure 1.
NIDA phenotyping battery domains.
Figure 2.
Figure 2.
PhAB Feasibility study enrollment
See this image and copyright information in PMC

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