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Review
. 2021 Apr 28;23(6):35.
doi: 10.1007/s11926-021-00999-8.

Axial Psoriatic Arthritis

Dafna D Gladman  1
Affiliations
Review

Axial Psoriatic Arthritis

Dafna D Gladman. Curr Rheumatol Rep. .

Abstract

Purpose of review: To review current understanding of the prevalence, clinical features, outcome measures and recent therapeutic trials in axial psoriatic arthritis (axPsA).

Recent findings: The prevalence of axPsA is estimated at 40-50%. However, the definition of axPsA remains unclear, therefore these estimates may be inaccurate. Ax PsA appears to be distinct from ankylosing spondylitis in demographic, clinical, genetic and therapeutic features. Because of the lack of widely accepted definition of axPsA it has been difficult to design therapeutic trials for this domain of PsA. Several studies have demonstrated the uniquness of axPsA. Few recent trials suggest that therapies that work for peripheral arthritis also work for axPsA.

Keywords: Axial disease; Diagnosis; Prognosis; Psoriatic arthritis; Spondylitis.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
    1. Moll JMH, Wright V. Psoriatic arthritis. Seminars Athritis Rheum. 1973;3:55–78. - DOI
    1. Gladman DD, Shuckett R, Russell ML, Thorne JC, Schachter RK. Psoriatic arthritis - clinical and laboratory analysis of 220 patients. Quart J Med. 1987;62:127–41. - PubMed
    1. Gladman DD. Axial disease in psoriatic arthritis. Curr Rheumatol Rep. 2007;9:455–60. - DOI
    1. •• Chandran V. Psoriatic spondylitis or ankylosing spondylitis with psoriasis: same or different? Curr Opin Rheumatol. 2019;31:329–34 An excellent review of the question posed. Highlights the difficulty in classification of the two conditions. - DOI
    1. •• Feld J, Chandran V, Haroon N, Inman R, Gladman D. Axial disease in psoriatic arthritis and ankylosing spondylitis: a critical comparison. Nat Rev Rheumatol. 2018;14:363–71 This is a critical review of the literature addressing the question whether axial disease in psoriatic arthritis is different from that of ankylosing spondylitis and highlights some clinical, imaging, genetic, and therapeutic differences. - DOI

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