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Comment
. 2021 Apr 28;41(17):3749-3751.
doi: 10.1523/JNEUROSCI.2352-20.2021.

Amyloid β Clearance Is Disrupted by Depletion of Low-Density Lipoprotein Receptor-Related Protein 4 (LRP4) in Astrocytes

Javier Cavieres-Lepe  1 , Nicolás Stuardo  2
Affiliations
Comment

Amyloid β Clearance Is Disrupted by Depletion of Low-Density Lipoprotein Receptor-Related Protein 4 (LRP4) in Astrocytes

Javier Cavieres-Lepe et al. J Neurosci. .
No abstract available

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References

    1. Castellano JM, Kim J, Stewart FR, Jiang H, DeMattos RB, Patterson BW, Fagan AM, Morris JC, Mawuenyega KG, Cruchaga C, Goate AM, Bales KR, Paul SM, Bateman RJ, Holtzman DM (2011) Human apoE isoforms differentially regulate brain amyloid-β peptide clearance. Sci Transl Med 3:89ra57. 10.1126/scitranslmed.3002156 - DOI - PMC - PubMed
    1. Castellano JM, Deane R, Gottesdiener AJ, Verghese PB, Stewart FR, West T, Paoletti AC, Kasper TR, DeMattos RB, Zlokovic BV, Holtzman DM (2012) Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis. Proc Natl Acad Sci U S A 109:15502–15507. 10.1073/pnas.1206446109 - DOI - PMC - PubMed
    1. Clarke LE, Liddelow SA, Chakraborty C, Münch AE, Heiman M, Barres BA (2018) Normal aging induces A1-like astrocyte reactivity. Proc Natl Acad Sci U S A 115:E1896–E1905. 10.1073/pnas.1800165115 - DOI - PMC - PubMed
    1. Erb L, Woods LT, Khalafalla MG, Weisman GA (2019) Purinergic signaling in Alzheimer's disease. Brain Res Bull 151:25–37. 10.1016/j.brainresbull.2018.10.014 - DOI - PubMed
    1. Itagaki S, McGeer PL, Akiyama H, Zhu S, Selkoe D (1989) Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease. J Neuroimmunol 24:173–182. 10.1016/0165-5728(89)90115-x - DOI - PubMed

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