Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Apr 12:12:634584.
doi: 10.3389/fimmu.2021.634584. eCollection 2021.

The Eµ-hnRNP K Murine Model of Lymphoma: Novel Insights into the Role of hnRNP K in B-Cell Malignancies

Prerna Malaney  1 , María Velasco-Estevez  2 , Pedro Aguilar-Garrido  2 , Marisa J L Aitken  1 , Lauren E Chan  1 , Xiaorui Zhang  1 , Sean M Post  1 , Miguel Gallardo  2
Affiliations
Review

The Eµ-hnRNP K Murine Model of Lymphoma: Novel Insights into the Role of hnRNP K in B-Cell Malignancies

Prerna Malaney et al. Front Immunol. .

Abstract

B-cell lymphomas are one of the most biologically and molecularly heterogeneous group of malignancies. The inherent complexity of this cancer subtype necessitates the development of appropriate animal model systems to characterize the disease with the ultimate objective of identifying effective therapies. In this article, we discuss a new driver of B-cell lymphomas - hnRNP K (heterogenous nuclear ribonucleoprotein K)-an RNA-binding protein. We introduce the Eµ-Hnrnpk mouse model, a murine model characterized by hnRNP K overexpression in B cells, which develops B-cell lymphomas with high penetrance. Molecular analysis of the disease developed in this model reveals an upregulation of the c-Myc oncogene via post-transcriptional and translational mechanisms underscoring the impact of non-genomic MYC activation in B-cell lymphomas. Finally, the transplantability of the disease developed in Eµ-Hnrnpk mice makes it a valuable pre-clinical platform for the assessment of novel therapeutics.

Keywords: B-cell malignancies; Eµ-Hnrnpk; MYC; RNA-binding protein; diffuse large B cell lymphoma; hnRNP K; lymphoma; mouse model.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
hnRNP K binds to and regulates the stability and translation of the MYC transcript (created with BioRender.com).
Figure 2
Figure 2
Candidate genes, involved in lymphoma, identified in hnRNP K RIP-Seq datasets (39, 64) (created with BioRender.com).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, et al. . The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood (2016) 127(20):2375–90. 10.1182/blood-2016-01-643569 - DOI - PMC - PubMed
    1. Mugnaini EN, Ghosh N. Lymphoma. Prim Care (2016) 43(4):661–75. 10.1016/j.pop.2016.07.012 - DOI - PubMed
    1. Scott DW, Gascoyne RD. The tumour microenvironment in B cell lymphomas. Nat Rev Cancer (2014) 14(8):517–34. 10.1038/nrc3774 - DOI - PubMed
    1. Tsujimoto Y, Cossman J, Jaffe E, Croce CM. Involvement of the bcl-2 gene in human follicular lymphoma. Science (New York NY) (1985) 228(4706):1440–3. 10.1126/science.3874430 - DOI - PubMed
    1. Tsujimoto Y, Jaffe E, Cossman J, Gorham J, Nowell PC, Croce CM. Clustering of breakpoints on chromosome 11 in human B-cell neoplasms with the t(11 ; 14) chromosome translocation. Nature (1985) 315(6017):340–3. 10.1038/315340a0 - DOI - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources