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. 2021 Mar;59(1):26-32.
doi: 10.4274/tao.2020.5827. Epub 2021 Mar 26.

The Effect of Curcumin on the Prevention of Myringosclerosis in Rats

Özlem Akkoca  1 , Selda Kargın Kaytez  1 , Nihat Yumuşak  2 , Akif Sinan Bilgen  1 , Ali Kavuzlu  1 , Ramazan Öcal  1 , Hatice Çelik  1 , Necmi Arslan  1
Affiliations

The Effect of Curcumin on the Prevention of Myringosclerosis in Rats

Özlem Akkoca et al. Turk Arch Otorhinolaryngol. 2021 Mar.

Abstract

Objective: The aim of this study was to investigate the preventative effect of oral curcumin (CMN) on myringosclerosis (MS) in an experimental rat model.

Methods: The study included 21 female Wistar albino rats randomly separated into three groups. Group 1 was given no treatment (control group). In Group 2 and Group 3, the tympanic membrane (TM) was perforated using a sterile ear pick. The rats in Group 3 were administered oral CMN 200 mg/kg/day. All rats were sacrificed after 16 days. Otomicroscopic and histopathologic examinations were performed on the tympanic membranes.

Results: Histopathologic examinations revealed that there were statistically significant differences between Group 2 and Group 3 in terms of MS degrees (p<0.001) and mean thicknesses of TMs (p<0.001), but there were no differences between Group 1 and Group 3. In respect of MS detected by otomicroscopy, a statistically significant difference was determined between Groups 1 and 2 (p<0.001) and between Groups 2 and 3 (p<0.01), but there was no significant difference between Group 1 and Group 3 (p=0.575).

Conclusion: Orally administered CMN can prevent myringosclerosis formation in experimentally induced myringotomies.

Keywords: Myringosclerosis; animal experiment; curcumin; histology; microscopy; rats; tympanic membrane.

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Conflict of interest statement

Conflict of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
View of normal tympanic membrane (0 point scale) in (hematoxylin and eosin, original magnification x200)
Figure 2
Figure 2
Sclerotic areas and thickness in the tympanic membrane from Group 2
Figure 3
Figure 3
Sclerotic areas and thickness in the tympanic membrane from Group 3
See this image and copyright information in PMC

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