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Comparative Study
. 2021 Dec;43(1):737-742.
doi: 10.1080/0886022X.2021.1918556.

Apo A1/Apo B ratio and acute coronary syndrome among peritoneal dialysis patients

Tianlei Chen  1 , Min Yang  1
Affiliations
Comparative Study

Apo A1/Apo B ratio and acute coronary syndrome among peritoneal dialysis patients

Tianlei Chen et al. Ren Fail. 2021 Dec.

Abstract

Background: Acute coronary syndrome (ACS) is prevalent in continuous ambulatory peritoneal dialysis (CAPD) patients. However, the association between the apoprotein profile and ACS is not well known. Therefore, we aimed to investigate the relationship between apoproteins and ACS in CAPD patients.

Methods: Eighty-one CAPD patients were included in this retrospective study. The primary endpoint was ACS. Predictors were baseline apoprotein levels, particularly the ratio of apoprotein A1 (Apo A1)/apoprotein B (Apo B). Cox regression was used to determine the relationship between Apo A1/Apo B and ACS.

Results: During follow-up, 34 (41.98%) CAPD patients experienced an ACS. ACS patients had higher levels of total cholesterol (p = 0.03), low-density lipoprotein cholesterol (LDL-C) (p = 0.04), C-reactive protein (p = 0.01), and Apo B (p < 0.01). However, hemoglobin (p = 0.01) and Apo A1/Apo B (p < 0.01) were lower in the ACS group than the non-ACS group. Patients with Apo A1/Apo B ≥ 1.105 experienced fewer ACS compared with those with Apo A1/Apo B < 1.105 (33.33% vs. 75.56%, p = 0.03). In Cox regression, Apo A1/Apo B (RR, 0.06; 95% CI, 0.00-0.77; p = 0.03) was independently associated with ACS.

Conclusions: Apo A1/Apo B was strongly associated with ACS and may be considered as a predictor of future ACS in CAPD patients.

Keywords: Apoprotein A1; acute coronary syndrome; apoprotein B; continuous ambulatory peritoneal dialysis.

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Conflict of interest statement

This study was preceded by a preprinted version at https://doi.org/10.21203/rs.3.rs-76234/v1. The authors declare no conflict of interest.

Figures

Figure 1.
Figure 1.
Flowchart of patient selection.
Figure 2.
Figure 2.
ACS free survival curves according to Apo A1/Apo B. ACS: acute coronary syndrome; Apo A1: apolipoprotein A1; Apo B: apolipoprotein B.
Figure 3.
Figure 3.
ROC curves analysis for Apo A1/Apo B. Apo A1: apolipoprotein A1; Apo B: apolipoprotein B.
See this image and copyright information in PMC

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References

    1. Delles C, Vanholder R.. Chronic kidney disease, Clin Sci (London). 2017;131(3):225–226. - PubMed
    1. Go AS. Cardiovascular disease consequences of CKD, Semin Nephrol. 2016;36(4):293–304. - PubMed
    1. Chen T, Yang M.. Platelet-to-lymphocyte ratio is associated with cardiovascular disease in continuous ambulatory peritoneal dialysis patients. Int Immunopharmacol. 2020;78:106063. - PubMed
    1. Anavekar NS, McMurray JJ, Velazquez EJ, et al. . Relation between renal dysfunction and cardiovascular outcomes after myocardial infarction. N Engl J Med. 2004;351(13):1285–1295. - PubMed
    1. Lingel JM, Srivastava MC, Gupta A.. Management of coronary artery disease and acute coronary syndrome in the chronic kidney disease population-a review of the current literature. Hemodial Int. 2017;21(4):472–482. - PubMed

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