Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2021 Apr 30;128(9):1317-1319.
doi: 10.1161/CIRCRESAHA.121.319149. Epub 2021 Apr 29.

Old Drugs for an Old Pathology? Drug Repurposing for Calcific Aortic Valve Disease

Affiliations
Editorial

Old Drugs for an Old Pathology? Drug Repurposing for Calcific Aortic Valve Disease

Francesca Bartoli-Leonard et al. Circ Res. .
No abstract available

Keywords: Editorials; XPO1; aortic valve disease; calcification; drug repositioning.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest

None declared.

Figures

Figure 1.
Figure 1.. Industry-academia collaboration for drug repurposing.
Collaborative relations between, academia, industry, federal agencies and clinical institutes are required to effectively repurpose drugs.

Comment on

References

    1. Nkomo VT, Gardin JM, Skelton TN, Gottdiener J, Scott C, Enriquez-Sarano M. Burden of valvular heart diseases: a population-based study. Lancet. 368. 1005–1010. 2006 - PubMed
    1. Brescia AA, Deeb GM, Sang SLW, Tanaka D, Grossman PM, Sukul D, He C, Theurer PF, Clark M. et al. Surgical Explantation of Transcatheter Aortic Valve Bioprostheses: A Statewide Experience. Circ Cardiovasc Interv. Online ahead of print. 2021 - PMC - PubMed
    1. Dutta P, Kodigepalli KM, LaHaye S, Thompson W, Rains S, Nagel C, Thatcher K, Hinton R, Lincoln J. KPT-330 Prevents Aortic Valve Calcification via a Novel C/EBPβ Signalling Pathway. Circ Res. 2021; 128: xx-xxx. - PMC - PubMed
    1. Azmi AS, Uddin MH, Mohammad RM. The nuclear export protein XPO1-From biology to targeted therapy. Nat Rev Clin Oncol. 18. 152–169. 2021 - PubMed
    1. Huk DK, Austin B, Horne TE, Hinton RB, Ray WC, Heistad DD, Lincoln J. Valve Endothelial Cell-Derived TGFb1 Signaling Promotes Nuclear Localization of Sox9 in Interstitial Cells Associated with Attenuated Calcification. ATVB. 36. 328–338. 2016 - PMC - PubMed

Substances