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Review
. 2021 Jul:139:111599.
doi: 10.1016/j.biopha.2021.111599. Epub 2021 Apr 23.

Novel and emerging mutations of SARS-CoV-2: Biomedical implications

Elmira Mohammadi  1 , Fatemeh Shafiee  2 , Kiana Shahzamani  3 , Mohammad Mehdi Ranjbar  4 , Abbas Alibakhshi  5 , Shahrzad Ahangarzadeh  6 , Leila Beikmohammadi  7 , Laleh Shariati  8 , Soodeh Hooshmandi  9 , Behrooz Ataei  10 , Shaghayegh Haghjooy Javanmard  11
Affiliations
Review

Novel and emerging mutations of SARS-CoV-2: Biomedical implications

Elmira Mohammadi et al. Biomed Pharmacother. 2021 Jul.

Erratum in

Abstract

Coronavirus disease-19 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 virus strains has geographical diversity associated with diverse severity, mortality rate, and response to treatment that were characterized using phylogenetic network analysis of SARS-CoV-2 genomes. Although, there is no explicit and integrative explanation for these variations, the genetic arrangement, and stability of SARS-CoV-2 are basic contributing factors to its virulence and pathogenesis. Hence, understanding these features can be used to predict the future transmission dynamics of SARS-CoV-2 infection, drug development, and vaccine. In this review, we discuss the most recent findings on the mutations in the SARS-CoV-2, which provide valuable information on the genetic diversity of SARS-CoV-2, especially for DNA-based diagnosis, antivirals, and vaccine development for COVID-19.

Keywords: COVID-19; Genetic variation; Mutation; SARS-CoV-2; Spike protein.

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Conflict of interest statement

Authors declare no conflict of interests and/or commercial products or companies.

Figures

Fig. 1
Fig. 1
Schematic structure of SARS-CoV-2 genome.
Fig. 2
Fig. 2
Entropy plots of all submitted Spike protein sequences. The X-axis shows the positions of amino acids and the Y-axis shows entropy scores for individual positions in Spike protein. (A) Asia, (B) Europe, (C) Africa, (D) South America, (E) North America, and (F) Oceania. Entropy (Hx) values varied from 0 (high conservation) to 1.0 (hypervariable). The amino acids with entropy values less than 0.1 were considered as conserved.
See this image and copyright information in PMC

References

    1. Pachetti M., Marini B., Benedetti F., Giudici F., Mauro E., Storici P., Masciovecchio C., Angeletti S., Ciccozzi M., Gallo R.C., Zella D., Ippodrino R. Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant. J. Transl. Med. 2020;18:1–9. - PMC - PubMed
    1. Sanjuán R., Domingo-Calap P. Mechanisms of viral mutation. Cell. Mol. Life Sci. 2016;73(23):4433–4448. - PMC - PubMed
    1. Pybus O.G., Tatem A.J., Lemey P. Virus evolution and transmission in an ever more connected world. Proc. R. Soc. B Biol. Sci. 2015;282 20142878. - PMC - PubMed
    1. Carter-Timofte M.E., Jørgensen S.E., Freytag M.R., Thomsen M.M., Andersen N.-S.B., Al-Mousawi A., et al. Deciphering the role of host genetics in susceptibility to severe COVID-19. Front. Immunol. 2020:11. - PMC - PubMed
    1. Domingo E., Holland J. RNA virus mutations and fitness for survival. Annu. Rev. Microbiol. 1997;51(1):151–178. - PubMed

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