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. 2021 Apr 1;8(2):84-88.
doi: 10.3390/dermatopathology8020013.

Inter-Observer and Intra-Observer Variations in the Assessment of Epithelial Dysplasia in Oral Lichenoid Diseases

Marwa Zohdy  1   2 , Simone Cazzaniga  1   3 , Helga Nievergelt  1 , Roland Blum  1 , Valérie G A Suter  4 , Laurence Feldmeyer  1 , Helmut Beltraminelli  1
Affiliations

Inter-Observer and Intra-Observer Variations in the Assessment of Epithelial Dysplasia in Oral Lichenoid Diseases

Marwa Zohdy et al. Dermatopathology (Basel). .

Abstract

Oral lichen planus (OLP) and oral lichenoid lesions (OLL) can both present with histological dysplasia. Despite the presence of WHO-defined criteria for the evaluation of epithelial dysplasia, its assessment is frequently subjective (inter-observer variability). The lack of reproducibility in the evaluation of dysplasia is even more complex in the presence of a lichenoid inflammation. We evaluated dysplasia in 112 oral biopsies with lichenoid inflammation in order to study the inter-observer and the intra-observer variability.

Keywords: dysplasia; inter-observer; intra-observer; oral lichen planus; oral lichenoid disease; oral lichenoid lesion.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Pictures of an OLL, with magnification on different zones of the same lesion. (a) Overview, (b) detail of an area with no atypia, (c) detail of an area with the presence of atypical keratinocytes. The dysplasia grading among the four experts for the whole slide was as follows (first evaluation/second evaluation at 3 months. Expert 1: dysplasia grading 0/2; Expert 2: dysplasia grading 1/2; Expert 3: dysplasia grading 2/2; Expert 4: dysplasia grading 2/3. Dysplasia grading: 0 = none, 1 = mild, 2 = moderate, 3 = severe.
See this image and copyright information in PMC

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References

    1. Schlosser B.J. Lichen planus and lichenoid reactions of the oral mucosa. Dermatol. Ther. 2010;23:251–267. doi: 10.1111/j.1529-8019.2010.01322.x. - DOI - PubMed
    1. Silverman S., Gorsky M., Lozada-Nur F. A prospective follow-up study of 570 patients with oral lichen planus: Persistence, remission, and malignant association. Oral Surg. Oral Med. Oral Pathol. 1985;60:30–34. doi: 10.1016/0030-4220(85)90210-5. - DOI - PubMed
    1. Van den Haute V., Antoine J.L., Lachapelle J.M. Histopathological discriminant criteria between lichenoid drug eruption and idiopathic lichen planus: Retrospective study on selected samples. Dermatologica. 1989;179:10–13. doi: 10.1159/000248091. - DOI - PubMed
    1. Rotim Z., Bolanca Z., Rogulj A.A., Andabak M., Boras V.V., Vrdoljak D.V. Oral lichen planus and oral lichenoid reaction—An update. Acta Clin. Croat. 2015;54:516–520. - PubMed
    1. Van der Meij E.H., van der Waal I. Lack of clinicopathologic correlation in the diagnosis of oral lichen planus based on the presently available diagnostic criteria and suggestions for modifications. J. Oral Pathol. Med. 2003;32:507–512. doi: 10.1034/j.1600-0714.2003.00125.x. - DOI - PubMed