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. 2021 Apr 1;9(4):333.
doi: 10.3390/vaccines9040333.

Sex-Related Differences in Allelic Frequency of the Human Beta T Cell Receptor SNP rs1800907: A Retrospective Analysis from Milan Metropolitan Area

Elena M Varoni  1   2 , Giovanni Lodi  1 , Massimo Del Fabbro  1   3 , Andrea Sardella  1 , Antonio Carrassi  1 , Marcello Iriti  2   4   5 , Pasquale Tripputi  1
Affiliations

Sex-Related Differences in Allelic Frequency of the Human Beta T Cell Receptor SNP rs1800907: A Retrospective Analysis from Milan Metropolitan Area

Elena M Varoni et al. Vaccines (Basel). .

Abstract

This paper aims at retrospectively re-analyzing the different distribution, between males and females, in the allelic frequency of the human β T cell receptor (TCR β) single nucleotide polymorphism (SNPs) rs1800907 in Caucasian patients in the Milan metropolitan area. The allelic frequency significantly differed between sexes. Females showed higher frequency of C/C genotype than males, but lower T/C genotype (p < 0.0001). Heterozygous (T/C) versus homozygous (T/T + C/C) genotypes resulted in a different distribution of frequencies in males than in females, the latter possessing higher homozygosis (p < 0.0001). Within the limitations of this work (small number of included studies that concerned just a specific geographical area), allelic distribution according to sex might account the role of TCRβ-related SNPs in autoimmune diseases and further investigations are required to explain better this genetic background, in the perspective of a sex-related T cell immune responsiveness and auto-immunity.

Keywords: genotype distribution; heterozygosis; homozygosis; polymorphism.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Forest plot comparing the percentage of T/T genotype (events) over the T/T + T/C (total) in males versus females. T/T shows higher frequency in females.
Figure 2
Figure 2
Forest plot comparing the percentage of T/C genotype (events) over the TC + TT + CC (total) in males versus females. T/C shows higher frequency in females.
Figure 3
Figure 3
Forest plot comparing homozygotes genotypes (T/T and C/C) in males versus females. In males (plot above), C/C has higher frequency than T/T, while, in females, T/T has higher frequency than C/C.
See this image and copyright information in PMC

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