Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Jun;79(2):175-8.
doi: 10.1007/BF00280560.

Chromosomal localization of the gene for human glucosamine-6-sulphatase to 12q14

D A Robertson  1 , D F Callen, E G Baker, C P Morris, J J Hopwood
Affiliations

Chromosomal localization of the gene for human glucosamine-6-sulphatase to 12q14

D A Robertson et al. Hum Genet. 1988 Jun.

Abstract

Glucosamine-6-sulphatase (G6S), a lysosomal enzyme found in all cells, is involved in the catabolism of heparin, heparan sulphate, and keratan sulphate. Deficiency of G6S results in the accumulation of undegraded substrate and the lysosomal storage disorder mucopolysaccharidosis type IIID (Sanfilippo D syndrome). Regional mapping by in situ hybridization of a 3H-labelled human G6S cDNA probe to human metaphase chromosomes indicated that the G6S gene is localized to chromosome 12 at q14. The localization of the G6S gene to chromosome 12 was confirmed using the G6S cDNA clone in Southern blot hybridization analysis of DNA from human x mouse hybrid cell lines.

PubMed Disclaimer

References

    1. Cytogenet Cell Genet. 1978;22(1-6):182-5 - PubMed
    1. Ann Genet. 1986;29(4):235-9 - PubMed
    1. Eur J Pediatr. 1982 Mar;138(2):168-71 - PubMed
    1. Biochem J. 1985 Aug 1;229(3):579-86 - PubMed
    1. Biochem J. 1987 Sep 1;246(2):347-54 - PubMed

Publication types

LinkOut - more resources