SARS-CoV-2 Seroprevalence among Healthcare Workers in General Hospitals and Clinics in Japan

doi:10.3390/ijerph18073786

. 2021 Apr 5;18(7):3786.

doi: 10.3390/ijerph18073786.

SARS-CoV-2 Seroprevalence among Healthcare Workers in General Hospitals and Clinics in Japan

Tatsuya Yoshihara¹, Kazuya Ito^{2

3}, Masayoshi Zaitsu⁴, Eunhee Chung⁵, Izumi Aoyagi⁶, Yoshikazu Kaji⁷, Tomomi Tsuru⁸, Takuma Yonemura⁹, Koji Yamaguchi¹⁰, Shinichi Nakayama¹¹, Yosuke Tanaka¹², Nobuo Yurino¹³, Hideki Koyanagi¹⁴, Shunji Matsuki¹, Ryuji Urae¹⁵, Shin Irie¹⁵

Affiliations

¹ Clinical Research Center, SOUSEIKAI Fukuoka Mirai Hospital, Kashiiteriha 3-5-1, Higashi-ku, Fukuoka 813-0017, Japan.
² SOUSEIKAI Clinical Epidemiological Research Center, Kashiiteriha 3-5-1, Higashi-ku, Fukuoka 813-0017, Japan.
³ College of Healthcare Management, Takayanagi 960-4, Setaka-machi, Miyama 835-0018, Japan.
⁴ Department of Public Health, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi 321-0293, Japan.
⁵ SOUSEIKAI Global Clinical Research Center, Kashiiteriha 3-5-1, Higashi-ku, Fukuoka 813-0017, Japan.
⁶ Department of Internal Medicine, SOUSEIKAI Fukuoka Mirai Hospital, Kashiiteriha 3-5-1, Higashi-ku, Fukuoka 813-0017, Japan.
⁷ SOUSEIKAI Hakata Clinic, 6-18 Tenyamachi, Hakata-ku, Fukuoka 812-0025, Japan.
⁸ SOUSEIKAI PS Clinic, 6-18 Tenyamachi, Hakata-ku, Fukuoka 812-0025, Japan.
⁹ SOUSEIKAI Sumida Hospital, 1-29-1, Honjo, Sumida-ku, Tokyo 130-0004, Japan.
¹⁰ SOUSEIKAI Nishikumamoto Hospital, 1012 Koga, Tomiaimachi, Minami-ku, Kumamoto 861-4157, Japan.
¹¹ SOUSEIKAI Miyata Hospital, 1636 Honjo, Miyawaka, Fukuoka 823-0003, Japan.
¹² SOUSEIKAI Kanenokuma Hospital, 3-24-16 Kanenokuma, Hakata-ku, Fukuoka 812-0863, Japan.
¹³ SOUSEIKAI Shinyoshizuka Hospital, 7-6-29, Yoshizuka, Hakata-ku, Fukuoka 812-0041, Japan.
¹⁴ SOUSEIKAI Dodo Clinic, 1-31-13, Nakaikegami, Ota-ku, Tokyo 146-0081, Japan.
¹⁵ SOUSEIKAI, 3-5-1 Kashiiteriha, Higashi-ku, Fukuoka 813-0017, Japan.

PMID: 33916399
PMCID: PMC8038556
DOI: 10.3390/ijerph18073786

SARS-CoV-2 Seroprevalence among Healthcare Workers in General Hospitals and Clinics in Japan

Tatsuya Yoshihara et al. Int J Environ Res Public Health. 2021.

. 2021 Apr 5;18(7):3786.

doi: 10.3390/ijerph18073786.

Authors

Affiliations

¹ Clinical Research Center, SOUSEIKAI Fukuoka Mirai Hospital, Kashiiteriha 3-5-1, Higashi-ku, Fukuoka 813-0017, Japan.
² SOUSEIKAI Clinical Epidemiological Research Center, Kashiiteriha 3-5-1, Higashi-ku, Fukuoka 813-0017, Japan.
³ College of Healthcare Management, Takayanagi 960-4, Setaka-machi, Miyama 835-0018, Japan.
⁴ Department of Public Health, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi 321-0293, Japan.
⁵ SOUSEIKAI Global Clinical Research Center, Kashiiteriha 3-5-1, Higashi-ku, Fukuoka 813-0017, Japan.
⁶ Department of Internal Medicine, SOUSEIKAI Fukuoka Mirai Hospital, Kashiiteriha 3-5-1, Higashi-ku, Fukuoka 813-0017, Japan.
⁷ SOUSEIKAI Hakata Clinic, 6-18 Tenyamachi, Hakata-ku, Fukuoka 812-0025, Japan.
⁸ SOUSEIKAI PS Clinic, 6-18 Tenyamachi, Hakata-ku, Fukuoka 812-0025, Japan.
⁹ SOUSEIKAI Sumida Hospital, 1-29-1, Honjo, Sumida-ku, Tokyo 130-0004, Japan.
¹⁰ SOUSEIKAI Nishikumamoto Hospital, 1012 Koga, Tomiaimachi, Minami-ku, Kumamoto 861-4157, Japan.
¹¹ SOUSEIKAI Miyata Hospital, 1636 Honjo, Miyawaka, Fukuoka 823-0003, Japan.
¹² SOUSEIKAI Kanenokuma Hospital, 3-24-16 Kanenokuma, Hakata-ku, Fukuoka 812-0863, Japan.
¹³ SOUSEIKAI Shinyoshizuka Hospital, 7-6-29, Yoshizuka, Hakata-ku, Fukuoka 812-0041, Japan.
¹⁴ SOUSEIKAI Dodo Clinic, 1-31-13, Nakaikegami, Ota-ku, Tokyo 146-0081, Japan.
¹⁵ SOUSEIKAI, 3-5-1 Kashiiteriha, Higashi-ku, Fukuoka 813-0017, Japan.

PMID: 33916399
PMCID: PMC8038556
DOI: 10.3390/ijerph18073786

Abstract

Coronavirus disease 2019 (COVID-19) has become a serious public health problem worldwide. In general, healthcare workers are considered to be at higher risk of COVID-19 infection. However, the prevalence of COVID-19 among healthcare workers in Japan is not well characterized. In this study, we aimed to examine the seroprevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antibodies among 2160 healthcare workers in hospitals and clinics that are not designated to treat COVID-19 patients in Japan. The prevalence of SARS-CoV-2 immunoglobulin G was 1.2% in August and October 2020 (during and after the second wave of the pandemic in Japan), which is relatively higher than that in the general population in Japan (0.03-0.91%). Because of the higher risk of COVID-19 infection, healthcare workers should be the top priority for further social support and vaccination against SARS-CoV-2.

Keywords: COVID-19; SARS-CoV-2; antibody; healthcare workers; seroprevalence.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Cited by

Effectiveness of COVID-19 vaccination in healthcare workers in Shiga Prefecture, Japan.
Chano T, Yamashita T, Fujimura H, Kita H, Ikemoto T, Kume S, Morita SY, Suzuki T, Kakuno F. Chano T, et al. Sci Rep. 2022 Oct 21;12(1):17621. doi: 10.1038/s41598-022-22682-3. Sci Rep. 2022. PMID: 36271136 Free PMC article.
Serology suggests adequate safety measures to protect healthcare workers from COVID-19 in Shiga Prefecture, Japan.
Chano T, Morita SY, Suzuki T, Yamashita T, Fujimura H, Yuri T, Menju M, Tanaka M, Kakuno F. Chano T, et al. PLoS One. 2022 Jun 24;17(6):e0270334. doi: 10.1371/journal.pone.0270334. eCollection 2022. PLoS One. 2022. PMID: 35749426 Free PMC article.

References

1. Nawa N., Kuramochi J., Sonoda S., Yamaoka Y., Nukui Y., Miyazaki Y., Fujiwara T. Seroprevalence of SARS-CoV-2 IgG Antibodies in Utsunomiya City, Greater Tokyo, after first pandemic in 2020 (U-CORONA): A household- and population-based study. medRxiv. 2020 doi: 10.1101/2020.07.20.20155945. - DOI - PMC - PubMed
1. Ministry of Health, Labour and Welfare A Report of Antib. Prevalence Surveillance in Japan (Japanese) [(accessed on 15 March 2021)]; Available online: https://www.mhlw.go.jp/content/000734482.pdf.
1. Galanis P., Vraka I., Fragkou D., Bilali A., Kaitelidou D. Seroprevalence of SARS-CoV-2 antibodies and associated factors in healthcare workers: A systematic review and meta-analysis. J. Hosp. Infect. 2021;108:120–134. doi: 10.1016/j.jhin.2020.11.008. - DOI - PMC - PubMed
1. Hibino M., Iwabuchi S., Munakata H. SARS-CoV-2 IgG seroprevalence among medical staff in a general hospital that treated patients with COVID-19 in Japan: Retrospective evaluation of nosocomial infection control. J. Hosp. Infect. 2021;107:103–104. doi: 10.1016/j.jhin.2020.10.001. - DOI - PMC - PubMed
1. Tanaka A., Yamamoto S., Miyo K., Mizoue T., Maeda K., Sugiura W., Mitsuya H., Sugiyama H., Ohmagari N. Seroprevalence of antibodies against SARS-CoV-2 in a large national hospital and affiliated facility in Tokyo, Japan. J. Infect. 2021 doi: 10.1016/j.jinf.2021.01.010. - DOI - PMC - PubMed

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

Associated data

Actions

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations
Medical
- MedlinePlus Health Information
Miscellaneous
- NCI CPTAC Assay Portal

[1] Nawa N., Kuramochi J., Sonoda S., Yamaoka Y., Nukui Y., Miyazaki Y., Fujiwara T. Seroprevalence of SARS-CoV-2 IgG Antibodies in Utsunomiya City, Greater Tokyo, after first pandemic in 2020 (U-CORONA): A household- and population-based study. medRxiv. 2020 doi: 10.1101/2020.07.20.20155945. - DOI - PMC - PubMed

[2] Nawa N., Kuramochi J., Sonoda S., Yamaoka Y., Nukui Y., Miyazaki Y., Fujiwara T. Seroprevalence of SARS-CoV-2 IgG Antibodies in Utsunomiya City, Greater Tokyo, after first pandemic in 2020 (U-CORONA): A household- and population-based study. medRxiv. 2020 doi: 10.1101/2020.07.20.20155945. - DOI - PMC - PubMed

[3] Ministry of Health, Labour and Welfare A Report of Antib. Prevalence Surveillance in Japan (Japanese) [(accessed on 15 March 2021)]; Available online: https://www.mhlw.go.jp/content/000734482.pdf.

[4] Ministry of Health, Labour and Welfare A Report of Antib. Prevalence Surveillance in Japan (Japanese) [(accessed on 15 March 2021)]; Available online: https://www.mhlw.go.jp/content/000734482.pdf.

[5] Galanis P., Vraka I., Fragkou D., Bilali A., Kaitelidou D. Seroprevalence of SARS-CoV-2 antibodies and associated factors in healthcare workers: A systematic review and meta-analysis. J. Hosp. Infect. 2021;108:120–134. doi: 10.1016/j.jhin.2020.11.008. - DOI - PMC - PubMed

[6] Galanis P., Vraka I., Fragkou D., Bilali A., Kaitelidou D. Seroprevalence of SARS-CoV-2 antibodies and associated factors in healthcare workers: A systematic review and meta-analysis. J. Hosp. Infect. 2021;108:120–134. doi: 10.1016/j.jhin.2020.11.008. - DOI - PMC - PubMed

[7] Hibino M., Iwabuchi S., Munakata H. SARS-CoV-2 IgG seroprevalence among medical staff in a general hospital that treated patients with COVID-19 in Japan: Retrospective evaluation of nosocomial infection control. J. Hosp. Infect. 2021;107:103–104. doi: 10.1016/j.jhin.2020.10.001. - DOI - PMC - PubMed

[8] Hibino M., Iwabuchi S., Munakata H. SARS-CoV-2 IgG seroprevalence among medical staff in a general hospital that treated patients with COVID-19 in Japan: Retrospective evaluation of nosocomial infection control. J. Hosp. Infect. 2021;107:103–104. doi: 10.1016/j.jhin.2020.10.001. - DOI - PMC - PubMed

[9] Tanaka A., Yamamoto S., Miyo K., Mizoue T., Maeda K., Sugiura W., Mitsuya H., Sugiyama H., Ohmagari N. Seroprevalence of antibodies against SARS-CoV-2 in a large national hospital and affiliated facility in Tokyo, Japan. J. Infect. 2021 doi: 10.1016/j.jinf.2021.01.010. - DOI - PMC - PubMed

[10] Tanaka A., Yamamoto S., Miyo K., Mizoue T., Maeda K., Sugiura W., Mitsuya H., Sugiyama H., Ohmagari N. Seroprevalence of antibodies against SARS-CoV-2 in a large national hospital and affiliated facility in Tokyo, Japan. J. Infect. 2021 doi: 10.1016/j.jinf.2021.01.010. - DOI - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

SARS-CoV-2 Seroprevalence among Healthcare Workers in General Hospitals and Clinics in Japan

Affiliations

SARS-CoV-2 Seroprevalence among Healthcare Workers in General Hospitals and Clinics in Japan

Authors

Affiliations

Abstract

Conflict of interest statement

Similar articles

Cited by

References

MeSH terms

Substances

Associated data

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Miscellaneous