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. 2021 Apr 6;10(7):1524.
doi: 10.3390/jcm10071524.

Retinal Vascularization Analysis on Optical Coherence Tomography Angiography before and after Intraretinal or Subretinal Fluid Resorption in Exudative Age-Related Macular Degeneration: A Pilot Study

Thibaud Mathis  1   2 , Sarra Dimassi  1 , Olivier Loria  1   2 , Aditya Sudhalkar  3   4 , Alper Bilgic  3 , Philippe Denis  1 , Pierre Pradat  5 , Laurent Kodjikian  1   2
Affiliations

Retinal Vascularization Analysis on Optical Coherence Tomography Angiography before and after Intraretinal or Subretinal Fluid Resorption in Exudative Age-Related Macular Degeneration: A Pilot Study

Thibaud Mathis et al. J Clin Med. .

Abstract

The aim was to analyze the variations in macular vascularization on optical coherence tomography angiography (OCTA) according to the presence of intraretinal fluid (IRF) induced by exudative age-related macular degeneration (AMD). We included exudative AMD patients with IRF and/or subretinal fluid (SRF) and age-matched control eyes. All patients underwent a macular 6 × 6 mm swept-source OCTA. The mean perfusion density (MPD) and mean vascular density (MVD) were calculated in the superficial (SCP) and the deep (DCP) capillary plexus at two timepoints: during an episode of exudation (T0) and after its total resorption (T1). A total of 22 eyes in the IRF ± SRF group, 11 eyes in the SRF group and 11 eyes in the healthy group were analyzed. At T0, the IRF ± SRF group showed significantly lower MPD and MVD than healthy eyes in the SCP (p < 0.001) and DCP (p < 0.001). At T1, MPD and MVD significantly increased from T0 in the SCP (p = 0.027 and p = 0.0093) and DCP (p = 0.013 and p = 0.046) but remained statistically lower than in the healthy eyes. For the SRF group, only the DCP showed significantly lower MPD (p = 0.012) and MVD (p = 0.046) in comparison to the healthy eyes at T0. The present study shows that retinal vascular changes do occur in the case of exudative AMD.

Keywords: age-related macular degeneration; exudation; optical coherence tomography angiography.

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Conflict of interest statement

The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Post-acquisition analysis. MPD: mean perfusion density; MVD: mean vascular density.
Figure 2
Figure 2
Optical coherence tomography angiography representative images of the superficial capillary plexus at T0 in eyes with intraretinal fluid (A) and subretinal fluid (B) compared to healthy subjects (C).
Figure 3
Figure 3
Optical coherence tomography angiography representative images of the deep capillary plexus at T0 in eyes with intraretinal fluid (A) and subretinal fluid (B) compared to healthy subjects (C).
See this image and copyright information in PMC

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